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Forty\u2010two rats were divided into six groups as follows: control, ZO\u201025, ZO\u201050, VCM, VCM\u2009+\u2009ZO\u201025, and VCM\u2009+\u2009ZO\u201050. \u03b1\u2010Glycosidase, butyrylcholinesterase, aldose reductase, acetylcholinesterase, paraoxonase\u20101, and carbonic anhydrase enzyme activities were significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) decreased in VCM group when compared with the control group. ZO, supplied with VCM, significantly activated some of these enzyme in all tissues. The results of this study showed that ZO regulates abnormal increases and decreases in VCM\u2010induced metabolic enzyme activities in all tissues.<\/jats:p>","DOI":"10.1002\/jbt.22381","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T13:17:36Z","timestamp":1566911856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["The effects of zingerone against vancomycin\u2010induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-554X","authenticated-orcid":false,"given":"C\u00fcneyt","family":"\u00c7a\u011flayan","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Bingol University Bingol Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3171-0633","authenticated-orcid":false,"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bartin University Bartin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3216-1098","authenticated-orcid":false,"given":"Yeliz","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Nihat Delibalta G\u00f6le Vocational High School, Ardahan University Ardahan Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefa","family":"K\u00fc\u00e7\u00fckler","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-2479","authenticated-orcid":false,"given":"Fatih Mehmet","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Ataturk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5993-1668","authenticated-orcid":false,"given":"\u0130lhami","family":"Gul\u00e7in","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Atat\u00fcrk University Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.111"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1259-9"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9209-4"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702002000400007"},{"key":"e_1_2_8_1_6_1","author":"Demir Y.","year":"2019","journal-title":"Biotechnol. 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