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Half maximal inhibition concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values were obtained from the enzyme activity (%)\u2010[Voriconazole] graphs, whereas\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    values were calculated from the Lineweaver\u2010Burk graphs. According to the results, the IC\n                    <jats:sub>50<\/jats:sub>\n                    value of Voriconazole was 40.77\u2009nM for \u03b1\u2010glycosidase, while the mean inhibition constant (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    ) value was 17.47\u2009\u00b1\u20091.51\u2009nM for \u03b1\u2010glycosidase. The results make an important contribution to drug design and have pharmacological applications. In addition, the Voriconazole compound demonstrated excellent inhibitory effects against AChE and hCA isoforms I and II. Voriconazole had\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    values of 29.13\u2009\u00b1\u20093.57\u2009nM against hCA I, 15.92\u2009\u00b1\u20091.90\u2009nM against hCA II, and 10.50\u2009\u00b1\u20092.46\u2009nM against AChE.\n                  <\/jats:p>","DOI":"10.1002\/jbt.22385","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T03:56:23Z","timestamp":1567482983000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Inhibition profiles of Voriconazole against acetylcholinesterase, \u03b1\u2010glycosidase, and human carbonic anhydrase I and II isoenzymes"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2443-2372","authenticated-orcid":false,"given":"Fevzi","family":"Topal","sequence":"first","affiliation":[{"name":"Department of Chemical and Chemical Processing Technologies, Laboratory Technology Program, Gumushane Vocational School Gumushane University Gumushane Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7183"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270005283837"},{"key":"e_1_2_7_1_4_1","first-page":"242","volume":"7","author":"Ghannoum M. 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