{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:15:03Z","timestamp":1789002903322,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deltamethrin (DLM) is a synthesized organophosphorus acaricide and bug spray, broadly utilized for veterinary and farming purposes. Although its exposure to humans and animals causes toxicity in the kidney and other primary organs, our objective was to assess the defensive effects of sitagliptin (Sita) and additionally curcumin (Cur) in the DLM\u2010intoxicated rats\u2019 kidney. DLM\u2010intoxicated rats revealed a huge increase of various biochemical parameters in serum identified with kidney damage: uric acid, urea, and creatinine. DLM intoxication altogether increased renal lipid peroxidation, and critically restrained antioxidative biomarkers including superoxide dismutase, glutathione, and glutathione peroxidase. Likewise, it increased the tumor necrosis factor\u2010\u03b1, interleukin 6 (IL\u20106) and IL\u20101\u03b2 level in serum. Additionally, DLM intoxication diminished the outflow of the nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf2)\/heme oxygenase\u20101 (HO\u20101) pathway in rats. Both Sita and Cur act against DLM\u2010prompted serum along with renal tissue biochemical parameters when utilized alone or in a mix alongside DLM intoxication. Besides this, both Sita and Cur delivered synergetic nephroprotective, antioxidative, and anti\u2010inflammatory impacts. Consequently, it could be presumed that Sita as well as Cur administration can limit the poisonous impacts of DLM by their free radical\u2010scavenging, strong antioxidant, and Nrf2\/HO\u20101 pathway upregulation activity.<\/jats:p>","DOI":"10.1002\/jbt.22386","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T13:21:21Z","timestamp":1566912081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro\u2010inflammatory cytokines and Nrf2\/Ho\u20101 pathway"],"prefix":"10.1002","volume":"33","author":[{"given":"Wenbin","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pharmacy Qingdao Municipal Hospital, Shinan  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Qingdao Hiser Medical Center  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Qingdao Center Hospital  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagaraja","family":"Sreeharsha","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Clinical Pharmacy King Faisal University  Al\u2010Ahsa Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0510-2148","authenticated-orcid":false,"given":"Yushan","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Qingdao Municipal Hospital, Shinan  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8848"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(98)00114-0"},{"key":"e_1_2_5_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02200-7"},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00128-008-9474-x"},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-6-109"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70052004.x"},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2011.03.001"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25380"},{"key":"e_1_2_5_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.10.033"},{"key":"e_1_2_5_1_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S132537"},{"key":"e_1_2_5_1_12_1","first-page":"911","volume":"11","author":"Gao H.","year":"2019","journal-title":"Am. J. Transl. Res"},{"key":"e_1_2_5_1_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490688"},{"key":"e_1_2_5_1_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2018.1412485"},{"key":"e_1_2_5_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.01.028"},{"key":"e_1_2_5_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2017.10.001"},{"key":"e_1_2_5_1_17_1","first-page":"1867","volume":"39","author":"Lu L.","year":"2018","journal-title":"Oncol. Rep"},{"key":"e_1_2_5_1_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2018.1528648"},{"key":"e_1_2_5_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.12.003"},{"key":"e_1_2_5_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.153"},{"key":"e_1_2_5_1_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3FO60486A"},{"key":"e_1_2_5_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.05.001"},{"key":"e_1_2_5_1_23_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/66347"},{"key":"e_1_2_5_1_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.983017"},{"key":"e_1_2_5_1_25_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.893180"},{"key":"e_1_2_5_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2016.07.004"},{"key":"e_1_2_5_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2012.05.012"},{"key":"e_1_2_5_1_28_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.23736\/S0031-0808.18.03455-9","volume":"60","author":"Chellappan D. K.","year":"2018","journal-title":"Panminerva Med"},{"key":"e_1_2_5_1_29_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2018028386"},{"key":"e_1_2_5_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.058"},{"key":"e_1_2_5_1_31_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2017019457"},{"key":"e_1_2_5_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.007"},{"key":"e_1_2_5_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.051"},{"key":"e_1_2_5_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.045"},{"key":"e_1_2_5_1_35_1","author":"Wadhwa R.","year":"2019","journal-title":"J. Cell. Physiol"},{"key":"e_1_2_5_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-014-0148-4"},{"key":"e_1_2_5_1_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872211309666151030110015"},{"key":"e_1_2_5_1_38_1","first-page":"155","volume":"8","author":"Gupta G.","year":"2018","journal-title":"Bull. Pharm.Res"},{"key":"e_1_2_5_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.03.013"},{"key":"e_1_2_5_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.061"},{"key":"e_1_2_5_1_41_1","doi-asserted-by":"publisher","DOI":"10.1615\/IntJMedMushrooms.2019030351"},{"key":"e_1_2_5_1_42_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2018022258"},{"key":"e_1_2_5_1_43_1","first-page":"742","volume":"16","author":"Tiwari J.","year":"2017","journal-title":"EXCLI J"},{"key":"e_1_2_5_1_44_1","first-page":"109","volume":"60","author":"Gupta G.","year":"2018","journal-title":"Panminerva Med"},{"key":"e_1_2_5_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.138"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22386","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.22386","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T20:35:49Z","timestamp":1694205349000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/jbt.22386"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22386","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,27]]},"assertion":[{"value":"2019-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22386"}}