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Combination therapy has emerged as a novel anticancer strategy. The present study evaluates the cotreatment of \u03b3\u2010tocopherol and 5\u2010FU in enhancing the efficacy of chemotherapy against HT\u201029 colon cancer cells. Cytotoxic effect of this combination was examined using the 3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide assay and a synergistic effect was evaluated by a combination index technique. Nuclear morphology was studied via 4\u2032,6\u2010diamidino\u20102\u2010phenylindole staining and flow cytometric assays were conducted to identify molecular mechanisms of apoptosis and cell cycle progression. We investigated the expression of Cyclin D1, Cyclin E, Bax, and Bcl\u20102 by a quantitative real\u2010time polymerase chain reaction. The IC<jats:sub>50<\/jats:sub> values for 5\u2010FU and \u03b3\u2010tocopherol were 21.8\u2009\u2009\u00b1\u20092.5 and 14.4\u2009\u00b1\u20092.6\u2009\u03bcM, respectively, and also this combination therapeutic increased the percentage of apoptotic cells from 35%\u2009\u00b1\u20092% to 40%\u2009\u00b1\u2009\u20094% (<jats:italic>P<\/jats:italic>\u2009\u2009&lt;\u2009\u2009.05). Furthermore, incubation HT\u201029 colon cells with combined concentrations of two drugs caused significant accumulation of cells in the subGsubG1 phase. Our results presented the combination therapy with 5\u2010FU and \u03b3\u2010tocopherol as a novel therapeutic approach, which can enhance the efficacy of chemotherapy.<\/jats:p>","DOI":"10.1002\/jbt.22399","type":"journal-article","created":{"date-parts":[[2019,10,6]],"date-time":"2019-10-06T09:15:42Z","timestamp":1570353342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adjuvant therapy with \u03b3\u2010tocopherol\u2010induce apoptosis in HT\u201029 colon cancer via cyclin\u2010dependent cell cycle arrest mechanism"],"prefix":"10.1002","volume":"33","author":[{"given":"Roya","family":"Bazzaz","sequence":"first","affiliation":[{"name":"Department of Biology, Science and Research Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossain","family":"Bijanpour","sequence":"additional","affiliation":[{"name":"Department of Genetic and Bioengineering, Faculty of Engineering and Architecture Yeditepe University \u0130stanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed M. 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