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The major symptoms of IBD include pustules or abscesses, severe abdominal pain, diarrhea, fistula, and stenosis, which may directly affect the patient's quality of life. A variety of mediators can stimulate the circumstances of IBD, some examples include infections by microbes such as bacteria, perturbation of the immune system and the surrounding environment of the intestines. Severe colitis was stimulated in the experimental animals through administering 4% dextran sulfate sodium (DSS) which is mixed in water ad libitum for 6 days. Eriocitrin (30\u2009mg\/kg) was then administered to the experimental animals followed by the induction of severe colitis to evaluate the therapeutic prospective of eriocitrin against the colon inflammation stimulated by DSS. In this study, eriocitrin (30\u2009mg\/kg) demonstrated significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) attenuation activity against the DSS\u2010stimulated severe colitis in experimental animals. Eriocitrin counteracted all of the clinical deleterious effects induced by DSS, such as body\u2010weight loss, colon shortening, histopathological injury, accretion of infiltrated inflammatory cells at the inflamed region and the secretion of inflammatory cytokines. The results clearly showed that eriocitrin effectively attenuated DSS\u2010induced acute colitis in experimental animals.<\/jats:p>","DOI":"10.1002\/jbt.22400","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T15:25:34Z","timestamp":1570548334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Anti\u2010inflammatory effects of eriocitrin against the dextran sulfate sodium\u2013induced experimental colitis in murine model"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-0992","authenticated-orcid":false,"given":"Gang","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Talent Highland First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"},{"name":"Department of General Surgery First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-5656","authenticated-orcid":false,"given":"Wen","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Talent Highland First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"},{"name":"Department of General Surgery First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"},{"name":"Department of Gastroenterology First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Talent Highland First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"},{"name":"Department of General Surgery First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Xijing Hospital Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanni","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Talent Highland First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"},{"name":"Department of General Surgery First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangju","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"She","sequence":"additional","affiliation":[{"name":"Department of Talent Highland First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"},{"name":"Department of General Surgery First Affiliated Hospital of Xi'an Jiao Tong University  Xian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.4137\/CGast.S12731"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00551"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.34"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e318281334d"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00381.x"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224154"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60750-8"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2014.18.4.279"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9345-1"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.42"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000465522"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-012-0259-0"},{"key":"e_1_2_7_1_16_1","first-page":"170","volume":"23","author":"Patel H.","year":"2009","journal-title":"Can. 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