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CCK\u20108 and migration assays were used to detect the functions of IL\u20107, BIL, and microRNA (miR)\u2010125a on cell viability and migration. The miR\u2010125a level was changed by transfection, and tested by real\u2010time quantitative polymerase chain reaction. Additionally, Western blot tested the levels of inflammatory factors (IL\u20106 and tumor necrosis factor\u2010\u03b1), matrix metalloproteinases (MMPs), and pathway\u2010related proteins. Moreover, the enzyme\u2010linked immunosorbent assay also was used to detect inflammatory factor\u00a0levels. IL\u20107 was used to construct\u00a0an inflammatory injury model in ATDC5 cells. Based on this, BIL inhibited IL\u201017\u2010induced cell viability, migration, and expressions of inflammatory factors and MMPs. Furthermore, we found BIL negatively regulated miR\u2010125a, and the miR\u2010125a mimic could partly reverse the effects of BIL on IL\u201017\u2010injury. Finally, we showed that BIL inhibited the c\u2010Jun N\u2010terminal kinase (JNK) and nuclear factor kappa B (NF\u2010\u03baB) pathways, and the miR\u2010125a mimic had\u00a0the opposite effect. BIL inhibited IL\u201017\u2010induced inflammatory injury in ATDC5 cells by downregulation of miR\u2010125a via JNK and NF\u2010\u03baB signaling pathways.<\/jats:p>","DOI":"10.1002\/jbt.22405","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T15:27:45Z","timestamp":1570548465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bilobalide alleviates IL\u201017\u2010induced inflammatory injury in ATDC5 cells by downregulation of microRNA\u2010125a"],"prefix":"10.1002","volume":"33","author":[{"given":"Dongmei","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Cardiology Shengli Oilfield Central Hospital Dongying Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Shengli Oilfield Central Hospital Dongying Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5003-467X","authenticated-orcid":false,"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Shengli Oilfield Central Hospital Dongying Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Shengli Oilfield Central Hospital Dongying Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Shengli Oilfield Central Hospital Dongying Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Shengli Oilfield Central Hospital Dongying Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.137"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-018-4388-4"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00305"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.40.361"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2018.01.014"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1197-5"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000147"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3573-1"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000252"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.04.019"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.050"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13609"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00158.2010"},{"key":"e_1_2_8_1_15_1","first-page":"6616","volume":"22","author":"Tang S. 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