{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:05:50Z","timestamp":1760889950976,"version":"3.41.2"},"reference-count":75,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["474060\/2012\u20108"],"award-info":[{"award-number":["474060\/2012\u20108"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/21186\u20105","2018\/05286\u20103"],"award-info":[{"award-number":["2013\/21186\u20105","2018\/05286\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatic diseases leading to fibrosis affect millions of individuals worldwide and are a major public health challenge. Although, there have been many advances in understanding hepatic fibrogenesis, an effective therapy remains elusive. Studies focus primarily on activation of the hepatic stellate cells (HSCs), the principal fibrogenic cells in the liver; however, fewer numbers of studies have examined molecular mechanisms that deactivate HSC, controlling the profibrogenic phenotype. In the present study, we evaluated cellular and molecular actions of the chemical triclosan (TCS) in reverting activated HSCs to a quiesced phenotype. We demonstrated that the inhibition of the enzyme fatty acid synthase by TCS in activated HSCs promotes survival of the cells and triggers cellular and molecular changes that promote cellular phenotypic reversion, offering potentially new therapeutic directions.<\/jats:p>","DOI":"10.1002\/jbt.22413","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T14:12:09Z","timestamp":1573567929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The modulatory effect of triclosan on the reversion of the activated phenotype of LX\u20102 hepatic stellate cells"],"prefix":"10.1002","volume":"34","author":[{"given":"Juliana F.","family":"Miranda","sequence":"first","affiliation":[{"name":"Departamento de Biologia, Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d  Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia D.","family":"Scarinci","sequence":"additional","affiliation":[{"name":"Departamento de Biologia, Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d  Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia F.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Departamento de Biologia, Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d  Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Biologia, Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d  Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia R.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Departamento de Biologia, Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d  Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila F.","family":"de Morais","sequence":"additional","affiliation":[{"name":"Departamento de Biologia, Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d  Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osmar","family":"Malaspina","sequence":"additional","affiliation":[{"name":"Instituto de Bioci\u00eancias, Centro de Estudos de Insetos Sociais Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d  Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-8393","authenticated-orcid":false,"given":"Karen C. M.","family":"Moraes","sequence":"additional","affiliation":[{"name":"Departamento de Biologia, Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d  Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v7.i11.1450"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01928.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.01.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(82)90283-X"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.24.8681"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.003"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2005.09.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2868"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.09.002"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042127"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2006.12.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.03.013"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-018-0255-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11075"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2019.01.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.07.011"},{"key":"e_1_2_7_21_1","first-page":"303","volume":"7","author":"Weiskirchen R.","year":"2016","journal-title":"Front. Pharmacol"},{"key":"e_1_2_7_22_1","first-page":"3211","volume":"18","author":"Wang Z. F.","year":"2018","journal-title":"Mol. Med. Rep"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2000.102378"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23071571"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2018.4483"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.06.012"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.09.027"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1419119111"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2433"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/232946"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0872-6"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.12.044"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2018.02.018"},{"key":"e_1_2_7_34_1","first-page":"30219","volume":"1388","author":"Shmarakov I. O.","year":"2019","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.63.02.100"},{"key":"e_1_2_7_36_1","first-page":"954","volume":"1","author":"Colotti G.","year":"2018","journal-title":"Front. Biosci., Landmark Ed"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.02.005"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2598-5"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.189502803176"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.13102\/sociobiology.v63i4.1027"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162094"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.08.020"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2007.06.011"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2015.1025345"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.08.005"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03327-13"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5926-2-S1-S7"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.2741\/4067"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700612R"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.015"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2445-3"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4662"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2008.01826.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21449"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5007"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-1536-5-S1-S24"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.3019"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8287"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-1770-1"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2016.04.011"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2214-1"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2.6.803"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1159\/000374098"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.05.007"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0734-5"},{"key":"e_1_2_7_67_1","first-page":"28","volume":"14","author":"Chen W.","year":"2018","journal-title":"Reprod. Toxicol"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495049"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2018.11.017"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2010.0035"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2012.05.008"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2014.01.003"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.0065"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2012.12.001"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.06.002"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022414"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjbt.22413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.22413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T23:36:07Z","timestamp":1694129767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/jbt.22413"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22413","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"type":"print","value":"1095-6670"},{"type":"electronic","value":"1099-0461"}],"subject":[],"published":{"date-parts":[[2019,11,12]]},"assertion":[{"value":"2019-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22413"}}