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In the electrophoresis assay, SA did not inhibit the genotoxicity induced by the venom. However, CA partially inhibited DNA degradation. In the comet assay, SA and CA exerted an inhibitory effect on the venom\u2010induced fragmentation. Succinate dehydrogenase presented, in computational analyzes, favorable energies to the molecular bond to both the malonic acid and the phenolic compounds evaluated. In the enzymatic activity assays, SA inhibited succinate dehydrogenase and interfered in the interaction of malonic acid. Meanwhile, CA potentiated the inhibition exerted by the malonic acid. The results suggest transient interactions between toxins present in venoms and phenolic acids, mainly by hydrogen interactions, which corroborate with the data from previous works.<\/jats:p>","DOI":"10.1002\/jbt.22417","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T14:05:44Z","timestamp":1573567544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mitochondriotropic action and DNA protection: Interactions between phenolic acids and enzymes"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-5442","authenticated-orcid":false,"given":"Tatiane Silva","family":"de Abreu","sequence":"first","affiliation":[{"name":"Department of Chemistry, Biochemistry Laboratory Universidade Federal de Lavras (UFLA), Campus UFLA  Lavras Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-3993","authenticated-orcid":false,"given":"Mariana Aparecida","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry Laboratory Universidade Federal de Lavras (UFLA), Campus UFLA  Lavras Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Assaid","family":"Sim\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry Laboratory Universidade Federal de Lavras (UFLA), Campus UFLA  Lavras Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-9052","authenticated-orcid":false,"given":"Marcus Vinicius Cardoso","family":"Trento","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry Laboratory Universidade Federal de Lavras (UFLA), Campus UFLA  Lavras Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1471-5758","authenticated-orcid":false,"given":"Mateus Willian de Faria","family":"Eleut\u00e9rio","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry Laboratory Universidade Federal de Lavras (UFLA), Campus UFLA  Lavras Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-7311","authenticated-orcid":false,"given":"Luciana Lopes","family":"Silva Pereira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry Laboratory Universidade Federal de Lavras (UFLA), Campus UFLA  Lavras Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-3801","authenticated-orcid":false,"given":"Elaine Fontes Ferreira","family":"da Cunha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Computacional Chemistry Laboratory Universidade Federal de Lavras (UFLA), Campus UFLA  Lavras Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-6911","authenticated-orcid":false,"given":"Silvana","family":"Marcussi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biochemistry Laboratory Universidade Federal de Lavras (UFLA), Campus UFLA  Lavras Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/978-3-642-22144-6","volume-title":"Natural Products\u2013Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes","author":"Ramawat K. 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