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Daidzein (DZ), a dietary isoflavone having antioxidant and anti\u2010inflammatory activity, is investigated in this study for protective effects against cisplatin\u2010induced renal injury in rats. DZ (25, 50, or 100\u2009mg\/kg; intraperitoneally; 10 days) was administered along with Cisplatin, single dose,\u00a0on the 7th day of the experiment. On the 11th day, the rats were euthanized, and different samples were collected for analysis. Biochemical, histopathological, and molecular parameters were assessed to evaluate the effect of daidzein. Cisplatin injection resulted in renal dysfunction, lipid peroxidation that led\u00a0to consumption of antioxidants, exaggerated apoptosis, and inflammation. These changes were associated with increase in the signaling proteins. DZ attenuated the toxic effects of cisplatin on the kidney at 100\u2009mg\/kg dose. The study concludes with the finding that daidzein imparts protection against the nephrotoxic effect of Cisplatin and can be considered as a novel, potential therapy.<\/jats:p>","DOI":"10.1002\/jbt.22431","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T09:21:19Z","timestamp":1576228879000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["The dietary isoflavone daidzein mitigates oxidative stress, apoptosis, and inflammation in CDDP\u2010induced kidney injury in rats: Impact of the MAPK signaling pathway"],"prefix":"10.1002","volume":"34","author":[{"given":"Ameesha","family":"Tomar","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Cardiovascular Research Laboratory All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Cardiovascular Research Laboratory All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana Irfan","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Cardiovascular Research Laboratory All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Bisht","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Cardiovascular Research Laboratory All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas Chandra","family":"Nag","sequence":"additional","affiliation":[{"name":"Department of Anatomy All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-0775","authenticated-orcid":false,"given":"Dharamvir Singh","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Cardiovascular Research Laboratory All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1919-4701","authenticated-orcid":false,"given":"Jagriti","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Cardiovascular Research Laboratory All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b16-00473"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356587"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520614666140127105809"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31812dfe1e"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2112490"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90545.2008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5935\/0101-2800.20130052"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002256"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.67102.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61234-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0821-7"},{"key":"e_1_2_7_13_1","first-page":"1","author":"Ojha S.","year":"2016","journal-title":"Oxid. 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