{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:27:25Z","timestamp":1773700045175,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T00:00:00Z","timestamp":1579305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302450"],"award-info":[{"award-number":["81302450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Smoking is associated with an increased risk of respiratory diseases, including lung cancer and asthma. However, the mechanisms or diagnostic markers for smoking\u2010related diseases remain largely unknown. Here we investigated the role of cigarette smoke condensate (CSC) in the regulation of human bronchial epithelial cell (BEAS\u20102B) behavior. We found that exposure to CSC significantly inhibited BEAS\u20102B cell viability, impaired cell morphology, induced cell apoptosis, triggered oxidative damage, and promoted inflammatory response, which suggests a deleterious effect of CSC on bronchial epithelial cells. In addition, CSC markedly altered the expression of apoptosis\u2010associated protein factors, including p21, soluble tumor necrosis factor receptor 1, and Fas ligand. In sum, our study identified a panel of novel protein factors that may mediate the actions of CSC on bronchial epithelial cells and have a predictive value for the development and progression of smoking\u2010related diseases, thus providing insights into the development of potential diagnostic and therapeutic strategies against these diseases.<\/jats:p>","DOI":"10.1002\/jbt.22444","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T14:40:15Z","timestamp":1579358415000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of apoptosis\u2010associated protein factors distinctly expressed in cigarette smoke condensate\u2010exposed airway bronchial epithelial cells"],"prefix":"10.1002","volume":"34","author":[{"given":"Ben\u2010cheng","family":"Lin","sequence":"first","affiliation":[{"name":"Tianjin Institute of Environmental and Operational Medicine  Tianjin 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