{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:07:02Z","timestamp":1789168022500,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>HOXA cluster antisense RNA 2 (HOXA\u2010AS2) is a long noncoding RNA associated with the development of numerous cancers. But, whether HOXA\u2010AS2 exhibits a certain function in sepsis\u2010engendered acute kidney injury (AKI) remains uninvestigated. We strived to unveil the role of HOXA\u2010AS2 in sepsis\u2010engendered AKI. The expression of HOXA\u2010AS2 in sepsis patients, animal models and lipopolysaccharide (LPS)\u2010impaired HK\u20102 cells was primarily assessed via a real\u2010time quantitative polymerase chain reaction. The effects of HOXA\u2010AS2 on cell survival of HK\u20102 cells under LPS irritation were evaluated after overexpression of HOXA\u2010AS2. The correlation between HOXA\u2010AS2 and microRNA (miR)\u2010106b\u20105p was forecasted via bioinformatics software and verified by using a luciferase report system. Subsequently, the functions of miR\u2010106b\u20105p in LPS\u2010damaged HK\u20102 cells were reassessed. Western blot was used for the determination of Wnt\/\u03b2\u2010catenin and nuclear factor\u2010\u03baB (NF\u2010\u03baB) pathways. HOXA\u2010AS2 expression was decreased in sepsis patients, animal operation group and LPS\u2010irritated HK\u20102 cells. Overexpressed HOXA\u2010AS2 mollified LPS\u2010triggered impairment in HK\u20102 cells. In addition, a negative mediatory relation between HOXA\u2010AS2 and miR\u2010106b\u20105p was predicated. Synchronously, overexpressed miR\u2010106b\u20105p counteracted the protection of HOXA\u2010AS2 in LPS\u2010damaged HK\u20102 cells. Ultimately, Wnt\/\u03b2\u2010catenin and NF\u2010\u03baB pathways were hindered by HOXA\u2010AS2 via targeting miR\u2010106b\u20105p. HOXA\u2010AS2 exhibited protection in sepsis\u2010engendered AKI via targeting miR\u2010106b\u20105p and hindering the Wnt\/\u03b2\u2010catenin and NF\u2010\u03baB pathways.<\/jats:p>","DOI":"10.1002\/jbt.22453","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:48:41Z","timestamp":1581468521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Long noncoding RNA HOXA\u2010AS2 mediates microRNA\u2010106b\u20105p to repress sepsis\u2010engendered acute kidney injury"],"prefix":"10.1002","volume":"34","author":[{"given":"Huifeng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Emergency Tongchuan People's Hospital  Tongchuan Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine I Jining No. 1 People's Hospital  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-3237","authenticated-orcid":false,"given":"Zhen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine II Jining No. 1 People's Hospital  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"4449","volume":"17","author":"Zheng Y.","year":"2018","journal-title":"Mol. 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