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The aim of this study was to evaluate the cardioprotective effect of the combination of carvedilol (CARD) and liposomal resveratrol (LIPO RESV) against DOXR\u2010induced cardiomyopathy in rats. The results of the present study showed that DOXR administration significantly increased heart weight\/body weight ratio by 35.6%, creatine kinase\u2010MB (CK\u2010MB) by 40.6%, troponin\u2010I levels by 85%, and decreased reduced glutathione level and superoxide dismutase activity by 47% and 52%, respectively compared to the control group. Moreover, cardiac caspase\u20103 protein expression was upregulated by 51.6% vs the control group. In contrast, treatment of DOXR\u2010administered rats with CARD, RESV, or LIPO RESV and their combination for 6 weeks improved all the above\u2010mentioned measured parameters. In conclusion, concomitant administration of CARD and LIPO RESV exerted additive pharmacological effects in some measured parameters against DOXR\u2010induced cardiomyopathy and this may be a useful cardioprotective strategy.<\/jats:p>","DOI":"10.1002\/jbt.22492","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T05:39:48Z","timestamp":1584337188000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antioxidant, antiapoptotic, and antifibrotic effects of the combination of liposomal resveratrol and carvedilol against doxorubicin\u2010induced cardiomyopathy in rats"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-1403","authenticated-orcid":false,"given":"Abeer","family":"Alanazi","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-6462","authenticated-orcid":false,"given":"Laila","family":"Fadda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-8882","authenticated-orcid":false,"given":"Ahlam","family":"Alhusaini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.03.006"},{"key":"e_1_2_8_3_1","first-page":"1","volume":"3","author":"Jungsuwadee P.","year":"2016","journal-title":"Cardiovasc. 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