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This study aimed to evaluate the damaging effects of UV\u2010A radiation at different periods of exposure on rats' brains administered with ciprofloxacin. Ciprofloxacin administration in UV\u2010A exposed animals exaggerated the brain\u2010oxidative stress biomarkers and decreased the locomotor activity. Exposure of rats to UV\u2010A for 60\u2009minutes induced a significant increase of malondialdehyde (MDA), myeloperoxidase (MPO), and a decrease in the values of superoxide dismutase (SOD), glutathione (GSH) compared to a normal one; these changes were UV\u2010A exposure time\u2013dependent. However, the administration of vitamin C to the UV\u201060\u2010treated group decreased the values of MDA, MPO, and shifted the values of SOD, GSH toward the normal values. Vitamin C, probably due to its strong antioxidant properties, could improve and partially counteract the toxic effect of UV\u2010A on oxidative stress parameters and prevent the damage in rat's brain tissues.<\/jats:p>","DOI":"10.1002\/jbt.22495","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T21:59:38Z","timestamp":1585605578000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The possible neurobehavioral protective effects of natural antioxidant against phototoxicity attenuation of antimicrobial quinolone group in rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Rania","family":"Yahia","sequence":"first","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research (NODCAR)  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-526X","authenticated-orcid":false,"given":"Marwa A.","family":"Masoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research (NODCAR)  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed S.","family":"Sheded","sequence":"additional","affiliation":[{"name":"EVA Corporation for Cosmetics  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanaa A.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Pharmacology National Organization for Drug Control and Research (NODCAR)  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1PP05219E"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2010.08.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.11.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.20013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35041687"},{"volume-title":"The Veterinary Formulary","year":"2001","author":"Bishop Y.","key":"e_1_2_8_7_1"},{"key":"e_1_2_8_8_1","first-page":"898","volume-title":"Veterinary Pharmacology and Therapeutics","author":"Papich M. 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