{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:11:11Z","timestamp":1788963071123,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated the effects of chrysin (CHR) on nonalcoholic fatty liver disease (NAFLD) in mice. The NAFLD mouse model was established using a diet deficient in methionine and choline (MCD). CHR was shown to attenuate MCD\u2010induced hepatic fat accumulation, increase very low\u2010density lipoprotein (VLDL) secretion, and decrease hepatic oxidative stress in NAFLD mice. Inhibition of oxidative stress or direct suppression of protein kinase C (PKC) by CHR significantly reduced PKC activity in the liver, leading to a decrease in inhibitory phosphorylation of hepatocyte nuclear factor 4\u03b1 (HNF4\u03b1). The resulting activation of HNF4\u03b1 led to induced transcription of apolipoprotein B and VLDL secretion. Together, these results show that CHR effectively ameliorates MCD\u2010induced fatty liver in NAFLD mice by targeting the hepatic oxidative stress\/PKC\/HNF4\u03b1 signaling pathway.<\/jats:p>","DOI":"10.1002\/jbt.22497","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T09:05:55Z","timestamp":1585299955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4\u03b1\u2010dependent very low\u2010density lipoprotein"],"prefix":"10.1002","volume":"34","author":[{"given":"Yu","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Pharmacy College Xinxiang Medical University Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangfei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nanjing Maternity and Child Health Care Hospital Women's Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pharmacy College Xinxiang Medical University Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pharmacy College Xinxiang Medical University Xinxiang Henan China"},{"name":"Department of Occupational and Environmental Health, School of Public Health Xinxiang Medical University Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9543-3575","authenticated-orcid":false,"given":"Keshu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2011.596521"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204265"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28123"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26717"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.41"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12953-016-0092-y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.10.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.12.012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113196660676"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1006581"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.104496"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-019-01705-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116797"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.059"},{"key":"e_1_2_6_16_1","first-page":"64","volume":"4","author":"Sladek F. 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