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The interaction of the complexes with calf thymus DNA was analyzed with spectroscopic methods of ultraviolet\u2010visible absorption spectra, DNA competitive binding with ethidium bromide, circular dichroism spectra, and DNA melting experiments, and DNA viscosity measurements, indicating that the complexes bind to DNA primarily in the grooving mode. With respect to the ligands, the cytotoxicity in vitro of the complexes against Hela, A549, and MCF\u20107 cells was much enhanced, with most of the IC<jats:sub>50<\/jats:sub> values less than 50\u2009\u03bcM or even comparable with those of cisplatin.<\/jats:p>","DOI":"10.1002\/jbt.22510","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T06:52:45Z","timestamp":1587451965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reduced amino acid Schiff base containing ruthenium(III) complexes: Synthesis, characterization, DNA interaction, and in vitro cytotoxicity"],"prefix":"10.1002","volume":"34","author":[{"given":"Zhaokuo","family":"Zhang","sequence":"first","affiliation":[{"name":"Chemical Biology Key Laboratory of Hebei Province, College of Chemistry and Environmental Science Hebei University  Baoding 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