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Exposure to this toxin is associated with liver abnormalities and dysfunction. An important role played by excitatory amino acid transporters (EAATs) of the <jats:italic>slc1<\/jats:italic> gene family has been reported in liver injuries. To gain insight into a plausible effect of BPA exposure in the liver glutamate\/aspartate transport, using the human hepatoblastoma cell line HepG2, we report a BPA\u2010dependent dynamic regulation of SLC1A3 and SLC1A2. Through the use of radioactive [<jats:sup>3<\/jats:sup>H]\u2010\n<jats:sc>d<\/jats:sc>\u2010aspartate uptake experiments and immunochemical approaches, we characterized time and dose\u2010dependent regulation of the protein levels and function of these transporters after acute exposure to BPA. An increase in nuclear Yin Yang 1 was found. 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