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The goal of this study was to investigate the protective effect of ellagic acid (EA) against spinal cord and sciatica function in cuprizone (Cup)\u2010induced demyelination model. Animals were divided into six equal groups. The first group received tap water as the control. Cup group was treated with Cup (0.2% w\/w in fed). EA 100 group was orally treated with EA (100\u2009mg\/kg). EA\u2009+\u2009Cup groups were orally treated with three doses of 5, 50, and 100\u2009mg\/kg of EA plus Cup (0.2% w\/w). All groups received treatment for 42\u2009days. Open field, rotarod, and gait tests were done to evaluate the behavioral changes following Cup and\/or EA treatment. Also, lipid peroxidation, reactive oxygen species (ROS) content, antioxidant capacity, superoxide dismutase (SOD), and catalase enzymes activity in spinal cord was evaluated. Luxol fast blue (LFB) staining also the behavioral tests were performed to evaluate the model. Cup increased ROS levels and oxidative stress in their spinal cord tissues. Also, Cup reduced antioxidant capacity, SOD, and catalase activity. EA (especially at 100\u2009mg\/kg) prevented these abnormal changes. EA co\u2010treatment dose\u2010dependently was able to ameliorate behavioral impairments in mice that received Cup. EA might act as a protective agent in MS by modulating spinal cord function.<\/jats:p>","DOI":"10.1002\/jbt.22564","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T21:07:15Z","timestamp":1594242435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The effect of ellagic acid on spinal cord and sciatica function in a mice model of multiple sclerosis"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-4930","authenticated-orcid":false,"given":"Forouzan","family":"Khodaei","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"College of Animal Science and Veterinary Medicine Shanxi Agricultural University  Taigu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Javad","family":"Khoshnoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Food and Supplements Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepideh","family":"Heidaryfar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Heidari","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad H.","family":"Karimpour Baseri","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Addiction, School of Advanced Medical Technologies Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Azarpira","sequence":"additional","affiliation":[{"name":"Transplant Research Center, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-2944","authenticated-orcid":false,"given":"Marzieh","family":"Rashedinia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, School of Pharmacy Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Medicinal Plants Processing Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"34","volume":"16","author":"Sahraian M. 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