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Alpha\u2010lipoic acid (ALA) is a powerful antioxidant, which can scavenge reactive oxygen species (ROS). The effects of ALA against VPA\u2010stimulated brain injury were investigated. In this study, Sprague\u2010Dawley rats were divided as four groups: Group I, control rats; Group II, ALA\u2010administered rats (50\u2009mg\/kg\/d); Group III, VPA\u2010administered rats (0.5\u2009g\/kg\/d); Group IV: VPA\u2010 and ALA\u2010administered rats at the same dose and time. According to the results, VPA increased lipid peroxidation, protein carbonyl, advanced oxidation protein products, total oxidant status, nitric oxide levels and glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferase, adenosine deaminase, xanthine oxidase activities, decreased glutathione, total antioxidant capacity levels, catalase, superoxide dismutase, glutathione peroxidase, sodium\u2010potassium ATPase, and paraoxonase activities. Treatment with ALA reversed these effects. In conclusion, we may suggest that ALA may be a good candidate for prevention of VPA\u2010induced brain injury.<\/jats:p>","DOI":"10.1002\/jbt.22580","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T15:03:32Z","timestamp":1594739012000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Alpha\u2010lipoic acid prevents brain injury in rats administered with valproic acid"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-5943","authenticated-orcid":false,"given":"Ismet Burcu","family":"Turkyilmaz","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar","family":"Bilgin Sokmen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Giresun University Giresun Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-4363","authenticated-orcid":false,"given":"Refiye","family":"Yanardag","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpasa Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00314-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2003.00031.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nop005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.07.056"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327114554047"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327114561665"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12202"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-015-0796-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.072314"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09637486.2011.649250"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2009.08.009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2009.11.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760902988843"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.03.065"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-3701-1-12"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2017.08.005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-0158-0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(02)00217-6"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.5505\/tjtes.2015.15985"},{"key":"e_1_2_6_21_1","first-page":"112","volume-title":"Glutathione in Red Cell Metabolism a Manual of Biochemical Methods","author":"Beutler E.","year":"1975"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90247-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90286-3"},{"key":"e_1_2_6_25_1","first-page":"158","volume":"70","author":"Paglia D. 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