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In this study, a new series of thiazol\u2010(2(3<jats:italic>H<\/jats:italic>)\u2010ylideneamino)benzenesulfonamide derivatives were synthesized and also some inhibition parameters including IC<jats:sub>50<\/jats:sub> (hydratese) and inhibition constant values (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>, esterase) were determined. All studied compounds exhibited potent inhibition against these enzymes. They inhibited carbonic anhydrases (CAs) with the IC<jats:sub>50<\/jats:sub> values of 113 to 395.8\u2009nM (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>\u2009=\u200977.38\u2010319.59\u2009nM) for hCA I and 91.9 to 516\u2009nM (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>\u2009=\u200962.79\u2010425.89\u2009nM) for hCA II. Among the compounds, <jats:bold>5c<\/jats:bold> was found to be the most active one (<jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>: 77.38\u2009nM) for hCA I and <jats:bold>5g<\/jats:bold> was found for hCA II with the value of 62.79\u2009nM.<\/jats:p>","DOI":"10.1002\/jbt.22596","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:43:23Z","timestamp":1596761003000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Synthesis of new series of thiazol\u2010(2(3<i>H<\/i>)\u2010ylideneamino)benzenesulfonamide derivatives as carbonic anhydrase inhibitors"],"prefix":"10.1002","volume":"34","author":[{"given":"Nurcan","family":"Berber","sequence":"first","affiliation":[{"name":"Department of Food Technology \u00c7anakkale 18 Mart University  \u00c7anakakale Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art and Sciences Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u0131rat","family":"Vural","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art and Sciences Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Ergun","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art and Sciences Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-8857","authenticated-orcid":false,"given":"Nahit","family":"Gen\u00e7er","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art and Sciences Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oktay","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Art and Sciences Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-012-0273-x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hc.10109"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2013.10.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cc800033m"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.09.111"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E350"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1998.tb03904.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.200900195"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/157017812802139636"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5460.1960"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.10.5.575"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568013013359131"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.16.040176.001521"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(00)01174-0"},{"key":"e_1_2_6_17_1","volume-title":"Protease Inhibitors in AIDS Therapy","author":"Ogden R. 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