{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T01:07:53Z","timestamp":1783386473116,"version":"3.54.6"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to uncover the protective potentiality of resveratrol and dimethyl fumarate (DMF) in the liver of a chronic unpredictable mild stress (CUMS)\u2010induced depression animal model. Resveratrol and DMF significantly alleviated CUMS\u2010induced behavioral abnormalities in stressed rats through improving sucrose preference in sucrose preference test and decreasing immobility time in a forced swimming test. They also mitigated serum corticosterone levels and elevated serum serotonin levels, which were formerly disturbed in CUMS rats. The hepatoprotective effect is evidenced by improvement in hepatic histopathological examinations, as well as\u00a0normalized serum alanine aminotransferase and aspartate aminotransferase activities. Molecular signaling of resveratrol and DMF was estimated by diminishing hepatic expression of phosphorylated p38 mitogen\u2010activated protein kinase (MAPK), extracellular signal\u2010regulated kinase1\/2 (ERK1\/2), and c\u2010Jun N\u2010terminal kinase (JNK). Consequently, they improved the hepatic antioxidant and anti\u2010inflammatory activities as elaborated by the normalization of total antioxidant capacity, glutathione, malondialdehyde, nuclear factor\u2010\u03baB, tumor necrosis factor\u2010\u03b1, and myeloperoxidase levels. In addition, they inhibited hepatocyte apoptosis as evidenced by the increased expression of B\u2010cell lymphoma 2, the decreased expression of Bax, as well as\u00a0the suppressed activity of caspase\u20103. In conclusion, resveratrol and DMF purveyed a significant anti\u2010depressant effect, which may be mediated, at least in part, via inhibiting the MAPK\/ERK\/JNK pathway in the CUMS rat model.<\/jats:p>","DOI":"10.1002\/jbt.22627","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T15:41:19Z","timestamp":1600962079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The deleterious effect of stress\u2010induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK\/ERK\/JNK pathway"],"prefix":"10.1002","volume":"35","author":[{"given":"Mona A.","family":"Kortam","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam Mohamed","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy 6th of October University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0033-7215","authenticated-orcid":false,"given":"Nevine","family":"Fathy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"3","volume":"7","author":"Lepine J. P.","year":"2011","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2014.08.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.23.3095"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.150265"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050456"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.10.031"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-013-9264-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i47.9069"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12165"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8170-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065000"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.01.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"2357653","DOI":"10.1155\/2017\/2357653","volume":"2017","author":"Yang X.","year":"2017","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072682"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1283-7_13"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.47"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152807781696464"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200800148"},{"key":"e_1_2_7_20_1","first-page":"4285","volume":"23","author":"Meng J.","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00687-3"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90358.2008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1260"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2015.05.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61619-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15218"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0689-z"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00278"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.190132"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i25.4508"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.12.013"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12539"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087097"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.284"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200807010-00010"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107111"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(78)90118-8"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02260.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.12.038"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_7_43_1","first-page":"882","volume":"61","author":"Beutler E.","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90342-1"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12506462"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9303-2"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.04.006"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.01.004"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.11.009"},{"key":"e_1_2_7_51_1","first-page":"124","volume":"39","author":"Deng X.","year":"2014","journal-title":"Zhen. Ci. Yan. Jiu."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2014.06.014"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23441"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.09.123"},{"key":"e_1_2_7_55_1","first-page":"23","volume":"23","author":"Moore A.","year":"2018","journal-title":"Molecules"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.10.010"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.22627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T19:18:51Z","timestamp":1723663131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jbt.22627"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22627","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]},"assertion":[{"value":"2020-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22627"}}