{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T04:34:33Z","timestamp":1759206873998,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. In this study, we investigated the correlation between Q192R genotypic polymorphism of the PON1 enzyme and nasal\u2010polyp disease. The study examined 62 nasal\u2010polyp patients and 88 controls. PON1 Q192R polymorphism was determined using polymerase chain reaction\u2010restriction fragment length polymorphism. The genotype distribution of the PON1 gene was significantly different between nasal\u2010polyp patients (QQ\u2009=\u200969.35%, QR\u2009=\u200925.81%, RR\u2009=\u20094.83%) and healthy controls (QQ\u2009=\u200952.27%, QR\u2009=\u200944.31%, RR\u2009=\u20093.40%). Our results suggest that the PON1 QQ genotype (odds ratio [OR]\u2009=\u20092.066, <jats:italic>P<\/jats:italic>\u2009=\u2009.036) is associated with a higher risk of developing the nasal\u2010polyp disease while QR genotype (OR\u2009=\u20090.437, <jats:italic>P<\/jats:italic>\u2009=\u2009.021) showed a lower risk.<\/jats:p>","DOI":"10.1002\/jbt.22628","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T05:39:30Z","timestamp":1610257170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-7152","authenticated-orcid":false,"given":"Ayla","family":"Solmaz Avcikurt","sequence":"first","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Balikesir University  Balikesir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7092-8857","authenticated-orcid":false,"given":"Nahit","family":"Gencer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Literature Balikesir University  Balikesir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3469-2653","authenticated-orcid":false,"given":"Hasmet","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Balikesir University  Balikesir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2013.07.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489.2016.1186833"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.05.028"},{"key":"e_1_2_6_5_1","first-page":"1757","volume":"47","author":"Dilci A.","year":"2017","journal-title":"J. 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