{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:07:27Z","timestamp":1774282047061,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parkinson's disease (PD) is a complex neurodegenerative illness associated\u00a0with the loss or damage to neurons of the dopaminergic system in the brain. Few therapeutic approaches and considerable side effects of conventional drugs necessitate\u00a0a new therapeutic agent to treat patients with PD. Rhaponticin is a natural hydroxystilbene, found in herbal plants such as <jats:italic>Rheum rhaponticum<\/jats:italic>, and known to have desirable biological activity including anti\u2010inflammatory properties. However, the neuroinflammation on rhaponticin levels has only been investigated partially so far. So, the current study explored whether rhaponticin could ameliorate the pathophysiology observed in both the in vitro microglial BV\u20102 cells and the\u00a0in vivo (1\u2010methyl\u20104\u2010phenyl\u20101,2,3,5\u2010tetrahydropyridine [MPTP])\u2010mediated PD model. The results show rhaponticin significantly attenuated lipopolysaccharide (LPS)\u2010mediated microglial activation by suppressing nitric oxide\u00a0synthase in conjunction with abridged reactive oxygen species production together with proinflammatory mediator reduction. In vivo\u00a0rhaponticin treatment improves motor impairments as well as the loss of dopaminergic neurons in MPTP\u2010treated mice possibly through suppression via mediators of inflammation. Taken together, these results offer evidence that rhaponticin exerts anti\u2010inflammatory effects and neuroprotection in an LPS\u2010induced microglial model and the MPTP\u2010induced mouse models of PD.<\/jats:p>","DOI":"10.1002\/jbt.22631","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T15:34:37Z","timestamp":1601048077000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neuroprotective effect of rhaponticin against Parkinson disease: Insights from in vitro BV\u20102 model and in vivo MPTP\u2010induced mice model"],"prefix":"10.1002","volume":"35","author":[{"given":"Fangfang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neurology Huaihe Hospital of Henan University  Kaifeng City Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijun","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Beijing Beiya Orthopedics Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5075-5901","authenticated-orcid":false,"given":"Arunachalam","family":"Chinnathambi","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulaiman Ali","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-9846","authenticated-orcid":false,"given":"Hongan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315613447"},{"key":"e_1_2_7_3_1","first-page":"717","volume":"125","author":"Marino B. 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