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B12, sitagliptin, and their combination with DOX were administered to tumor\u2010bearing mice for 21 days. Treatment with B12, sitagliptin, as well as their combinations with DOX caused a significant inhibition of tumor growth and increased the survival time. Malondialdehyde levels and the relative expression of tumor necrosis factor\u2010\u03b1 and nuclear factor kappa B were significantly decreased, whereas the total antioxidant capacity was significantly increased in all treated groups, except the DOX\u2010treated one, when compared with the positive control group. Moreover, increased apoptosis was also observed by increased cleaved caspase\u20103 immunostaining and histopathological examination. In conclusion, the antitumor activity of B12 and sitagliptin could be attributed to their ability to induce apoptosis and suppress oxidative stress and inflammation.<\/jats:p>","DOI":"10.1002\/jbt.22645","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T09:33:37Z","timestamp":1601890417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antitumor activity of sitagliptin and vitamin B12 on Ehrlich ascites carcinoma solid tumor in mice"],"prefix":"10.1002","volume":"35","author":[{"given":"Rania","family":"Salah","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0002-9108","authenticated-orcid":false,"given":"Mohamed F.","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebatallah A.","family":"Mahgoub","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u2010Said","family":"El\u2010Sherbini","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"20","volume":"111","author":"Hrubisko M.","year":"2010","journal-title":"Bratisl. 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