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Glabrene administration (25, 50, and 100\u2009mg\/kg) for 13 weeks can significantly slow down the body weight gain and slightly increase the uterus weight of OVX rats. The increased levels of U\u2010Ca, U\u2010P levels, urine DPD\/creatinine, serum ALP, OCN, triglycerides, and total cholesterol induced by OVX were dramatically inhibited in rats, whereas no difference occurred for S\u2010Ca and S\u2010P in all groups. Furthermore, glabrene can enhance bone mineral density of the right femur, fourth\u2010lumbar vertebra and tibia and improve biomechanical parameters, such as femoral neck loading force, three\u2010point bending of the tibia, and vertebral compression in OVX rats. Moreover, glabrene greatly suppressed the expression of TRAP protein but increased OPG and BGP protein expression in tibia tissue of OVX rats. In addition, OVX\u2010induced reduction of Lrp\u20105, \u03b2\u2010catenin, Runx2, and Osx protein expression was all restored by glabrene treatment. The present study indicated that glabrene might be a potential alternative medicine for the prevention and treatment of postmenopausal osteoporosis via activation of the Wnt\/\u03b2\u2010catenin signaling pathway.<\/jats:p>","DOI":"10.1002\/jbt.22653","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T21:03:17Z","timestamp":1603918997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The phytoestrogen glabrene prevents osteoporosis in ovariectomized rats through upregulation of the canonical Wnt\/\u03b2\u2010catenin signaling pathway"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-7920","authenticated-orcid":false,"given":"Jun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Spine Surgery Maoming People's Hospital Maoming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Maoming People's Hospital Maoming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Maoming People's Hospital Maoming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Maoming People's Hospital Maoming China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2016.048"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.01.040"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12766"},{"key":"e_1_2_9_5_1","first-page":"328","volume":"24","author":"Al\u2010Sabbagh M.","year":"2015","journal-title":"Implant. 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