{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:35:49Z","timestamp":1784709349627,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Malaria continues to become a major global health problem, particularly in Sub\u2010Saharan Africa, Asia, and Latin America. The widespread emergence of resistance to first\u2010line drugs has further bolstered an urgent need for a new and cost\u2010effective antimalarial(s). Thus, the present study enumerates the synthesis of novel hybrid dimethoxy pyrazole 1,3,5\u2010triazine derivatives\u00a0<jats:bold>7<\/jats:bold>(<jats:bold>a<\/jats:bold>\u2013<jats:bold>j<\/jats:bold>) and their <jats:italic>in silico<\/jats:italic> results short\u2010listed three compounds with good binding energies and dock scores. Docking analysis shows that hydrogen\u2010bonding predominates and typically involves key residues, such as Asp54, Tyr170, Ile164, and Arg122. The in vitro antimalarial evaluation of three top\u2010ranked compounds (<jats:bold>7e<\/jats:bold>, <jats:bold>7g<\/jats:bold>, and <jats:bold>7h<\/jats:bold>) showed half\u2010maximal inhibitory concentration\u00a0values range from 53.85 to 100\u2009\u03bcg\/ml against chloroquine\u2010sensitive strain 3D7 of <jats:italic>Plasmodium falciparum<\/jats:italic>. Compound <jats:bold>7e<\/jats:bold> may be utilized as a lead for further optimization work in drug discovery due to good antimalarial activity.<\/jats:p>","DOI":"10.1002\/jbt.22682","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T09:38:07Z","timestamp":1608284287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["In silico study, synthesis, and evaluation of the antimalarial activity of hybrid dimethoxy pyrazole 1,3,5\u2010triazine derivatives"],"prefix":"10.1002","volume":"35","author":[{"given":"Pinku","family":"Gogoi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University  Dibrugarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshul","family":"Shakya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University  Dibrugarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit K.","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University  Dibrugarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelutpal","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University  Dibrugarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Gahtori","sequence":"additional","affiliation":[{"name":"School of Pharmacy Graphic Era Hill University  Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nardev","family":"Singh","sequence":"additional","affiliation":[{"name":"School of Pharmacy Graphic Era Hill University  Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dibya R.","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Regional Medical Research Centre Indian Council of Medical Research (ICMR)  Dibrugarh Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udaya P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Drug Design and Discovery Laboratory Sam Higginbottom University of Agriculture Technology and Sciences  Allahabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9643-4916","authenticated-orcid":false,"given":"Hans R.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University  Dibrugarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Malaria Report.\u00a0http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/275867\/9789241565653-eng.pdf\u00a0(accessed: 2018)."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4381"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.09.093"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21682"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.64.12"},{"key":"e_1_2_8_7_1","first-page":"CD008492","volume":"10","author":"Gogtay N.","year":"2013","journal-title":"Cochrane Database Syst. 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