{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:35:29Z","timestamp":1784903729260,"version":"3.55.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The present study examined the influence of selenium on ciprofloxacin\u2010mediated reproductive dysfunction in rats. The research design consisted of five groups of eight animals each. The rats were administered 135\u2009mg\/kg body weight of ciprofloxacin per se or simultaneously with selenium at 0.25 and 0.5\u2009mg\/kg for 15 uninterrupted days. Antioxidant and inflammatory indices were assayed using the testes, epididymis, and hypothalamus of the animals after sacrifice. Results revealed that ciprofloxacin treatment per se interfered with the reproductive axis as demonstrated by diminished serum hormonal levels, sperm quality, and enzymatic indices of testicular function, which were, however, abrogated following selenium co\u2010treatment. Besides this, administration of selenium attenuated the depletion of glutathione level, inhibition of catalase, superoxide dismutase, glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferase and glutathione peroxidase activities with a concomitant reduction in reactive oxygen and nitrogen species, and lipid peroxidation in ciprofloxacin\u2010treated in rats. Selenium treatment also mitigated ciprofloxacin\u2010mediated elevation in nitric oxide level and of myeloperoxidase activity as well as histological lesions in the animals. Overall, selenium attenuated impairment in the male reproductive axis due to ciprofloxacin treatment through abatement of inflammation and oxidative stress in rats.<\/jats:p>","DOI":"10.1002\/jbt.22741","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T23:35:22Z","timestamp":1613777722000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Abatement of the dysfunctional hypothalamic\u2013pituitary\u2013gonadal axis due to ciprofloxacin administration by selenium in male rats"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5997-178X","authenticated-orcid":false,"given":"Isaac A.","family":"Adedara","sequence":"first","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifeoluwa O.","family":"Awogbindin","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija A.","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatobiloba F.","family":"Da\u2010Silva","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer O.","family":"Farombi","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine University of Ibadan Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13890"},{"key":"e_1_2_7_3_1","first-page":"85","volume":"14","author":"Nickel J. C.","year":"2020","journal-title":"Can. Urol. Assoc. J."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-018-3212-z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/01485019808987939"},{"key":"e_1_2_7_6_1","first-page":"125","volume":"13","author":"Khaki A.","year":"2015","journal-title":"Iran. J. Reprod. Med."},{"key":"e_1_2_7_7_1","first-page":"294","volume":"6","author":"Zobeiri F.","year":"2013","journal-title":"Int. J. Fertil. Steril."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/2305-0500.281078"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2019.113268"},{"key":"e_1_2_7_10_1","first-page":"131","volume":"3","author":"Zobeiri F.","year":"2012","journal-title":"Vet. Res. Forum"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3MT00185G"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2017.11.056"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.03.116"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.08.002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-15-0156"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-019-00769-z"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2014.01.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/reveh-2019-0008"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.003822"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.656363"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2019.7905"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S157541"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10695-018-0556-3"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-020-08294-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.08.048"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.07.015"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12590"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.12.019"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001179"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2019.05.007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-011-0276-4"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0580"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.113079"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2013.12.006"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520620666200331102609"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2020.1835898"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2013.08.012"},{"key":"e_1_2_7_38_1","first-page":"4","volume-title":"Laboratory Manual for the Examination of Human Semen and Sperm\u2010Cervical Mucus\u00a0Interaction","author":"World Health Organization","year":"1999"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-009-9443-3"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.12782"},{"key":"e_1_2_7_42_1","first-page":"118","volume-title":"Methods of Enzymatic Analysis","author":"Vassault A.","year":"1983"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.11.001"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)45228-9"},{"key":"e_1_2_7_45_1","first-page":"237","volume-title":"Handbook of Methods for Oxygen Radical Research","author":"Claiborne A.","year":"1995"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42083-8"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.179.4073.588"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000136485"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-016-1852-x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(00)00039-9"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(82)90118-X"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000049948.64660.06"},{"key":"e_1_2_7_53_1","first-page":"83","volume-title":"Theory and Practice of Histology Techniques","author":"Bancroft J. D.","year":"2008"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-008-8287-4"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6050050"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(90)90078-T"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0310149"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.120.019240"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2013.834359"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ17-0001"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn004"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/aja.2010.183"},{"key":"e_1_2_7_65_1","first-page":"71","volume":"6","author":"Khaki A.","year":"2008","journal-title":"Iranian J. Reprod. Med."}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22741","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.22741","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:24:04Z","timestamp":1693351444000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/jbt.22741"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22741","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,16]]},"assertion":[{"value":"2020-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22741"}}