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The aim of this study was to investigate the potential protective effect of apigenin in a rat model of polymicrobial sepsis. Eight groups consisting of a total of 64 female Wistar albino rats were used for this study. Pro\u2010inflammatory (TNF\u2010\u03b1, IL\u20101\u2010\u03b2, IL\u20106) and anti\u2010inflammatory (TGF\u2010\u03b2, IL\u201010) cytokine levels were measured with the enzyme\u2010linked immunosorbent assay technique, oxidant\/antioxidants parameters were measured using the spectrophotometric method and Bax and Caspase\u20103 immunohistochemical methods. TNF\u2010\u03b1, TGF\u2010\u03b2, IL\u20101\u03b2, and IL\u20106 levels significantly increased in the sepsis\u2010induced group than in the control groups, while IL\u201010 levels decreased. Lipid peroxidase (LPO), an oxidative stress marker, increased, while the antioxidant defense parameters of superoxide dismutase (SOD), catalase (CAT) activities, glutathione (GSH) levels decreased. Although Bax and Caspase\u20103 immunoreactivity and <jats:italic>H<\/jats:italic> score levels significantly increased in the sepsis group, significant decreases were found in the groups treated with apigenin. In conclusion, we are of the opinion that apigenin treatment improves lung injury by inhibiting oxidative stress and inflammatory cell damage.<\/jats:p>","DOI":"10.1002\/jbt.22743","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T22:21:57Z","timestamp":1613859717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Investigation of oxidant\/antioxidant and anti\u2010inflammatory effects of apigenin on apoptosis in sepsis\u2010induced rat lung"],"prefix":"10.1002","volume":"35","author":[{"given":"Mustafa","family":"Cicek","sequence":"first","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Kahramanmaras S\u00fctc\u00fc Imam University  Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-0563","authenticated-orcid":false,"given":"Velid","family":"Unsal","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences Mardin Artuklu University  Mardin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adem","family":"Doganer","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Faculty of Medicine Kahramanmaras S\u00fctc\u00fc Imam University  Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Faculty of Medicine Kahramanmaras S\u00fctc\u00fc Imam University  Kahramanmaras Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2843"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F305"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130327"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/315214"},{"key":"e_1_2_9_7_1","first-page":"608","volume-title":"Cellular and Molecular Immunology","author":"Abbas A. 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