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Therefore, this study aims to explore the anti\u2010fibrotic effects of low dose of paclitaxel (PTX) against thioacetamide (TAA)\u2010induced liver fibrosis in rats and the possible mechanisms involved. TAA was administered at a dose of 200\u2009mg\/kg twice weekly for 6 weeks in rats to induce liver fibrosis similar to that in humans. Liver dysfunction was shown by increased alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and \u03b3\u2010glutamyl transferase, along with histopathological changes. Liver fibrosis was confirmed by Masson's Trichome staining, increased collagen content, and elevated \u03b1\u2010smooth muscle actin (\u03b1\u2010SMA) protein expression. In addition, TAA induced liver apoptosis as indicated by the increased terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)\u2010positive cells in liver tissues. This study demonstrated that the administration of PTX (0.3\u2009mg\/kg\/i.p.) three times a week for 6 weeks significantly alleviated functional and biochemical changes induced by TAA in addition to improving the liver architecture. PTX attenuated liver fibrosis as reflected by the decreased collagen content and \u03b1\u2010SMA protein expression. Additionally, PTX attenuated liver apoptosis as indicated by the decreased TUNEL\u2010positive cells. Moreover, PTX prevented TAA\u2010induced elevation of transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21), platelet\u2010derived growth factor\u2010BB (PDGF\u2010BB), and tissue inhibitor of metalloproteinase 1 (TIMP\u20101) levels in liver tissues. These findings suggest that the low dose of PTX prevented TAA\u2010induced liver fibrosis in rats, possibly by\u00a0inhibiting the expression of TGF\u2010\u03b21 and PDGF\u2010BB and subsequently suppressing the apoptosis and the expression of TIMP\u20101.<\/jats:p>","DOI":"10.1002\/jbt.22745","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T07:26:06Z","timestamp":1616397966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Protective effects of paclitaxel on thioacetamide\u2010induced liver fibrosis in a rat model"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-2605","authenticated-orcid":false,"given":"Maha H.","family":"Sharawy","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Faculty of Pharmacy, Mansoura University Mansoura 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