{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:18:11Z","timestamp":1787066291909,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:00:00Z","timestamp":1615334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Tuberculosis, an airborne infectious disease, results in a high morbidity and mortality rate. The continuous emergence of TB resistance strains including MDR (multidrug\u2010resistant tuberculosis), XDR (extensive drug\u2010resistant tuberculosis), and especially TDR (totally drug\u2010resistant tuberculosis) is a major\u00a0public health threat and has intensified\u00a0the need to develop new antitubercular agents. A natural product, curcumin,\u00a0possesses diverse biological activities but suffers due to a\u00a0lack of water solubility and bioavailability. To overcome these limitations, a series of\n                    <jats:bold>17<\/jats:bold>\n                    water\u2010soluble monocarbonyl curcuminoids was synthesized and evaluated for antimycobacterial activity. All compounds exhibited good to moderate anti\u2010TB activity with MIC\n                    <jats:sub>99<\/jats:sub>\n                    in the range of 3.12\u201325.0\u2009\u00b5M, out of which\n                    <jats:bold>7c<\/jats:bold>\n                    and\n                    <jats:bold>7p<\/jats:bold>\n                    were found the most potent compounds with MIC\n                    <jats:sub>99<\/jats:sub>\n                    in the range of 3.12\u20136.25\u2009\u00b5M. Furthermore, these compounds were observed to be nonhaemolytic, nontoxic, and stable under both physiological as well as reducing conditions. In\u2010vitro metabolic stability data of the representative compound\n                    <jats:bold>7p<\/jats:bold>\n                    with the human liver microsome revealed that these compounds possess a moderate metabolism with a half\u2010life of 1.2\u2009h and an intrinsic clearance of 1.12\u2009ml\/h\/mg.\n                  <\/jats:p>","DOI":"10.1002\/jbt.22754","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T07:47:26Z","timestamp":1615362446000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Monocarbonyl curcuminoids as antituberculosis agents with their moderate in\u2010vitro metabolic stability on human liver microsomes"],"prefix":"10.1002","volume":"35","author":[{"family":"Gagandeep","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Delhi  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Singh","sequence":"additional","affiliation":[{"name":"Tuberculosis Research Laboratory Translational Health Science and Technology Institute  Faridabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqib","family":"Kidawi","sequence":"additional","affiliation":[{"name":"Tuberculosis Research Laboratory Translational Health Science and Technology Institute  Faridabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujjalkumar S.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Ocular Pharmacology, Dr. R. 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