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In the current experimental study, we planned to scrutinize the therapeutic potential of geraniin against ovariectomy (OVX)\u2010induced osteoporosis in rats and find the possible mechanism. Healthy Sprague Dawley rats were randomized into six groups and subjected to geraniin and alendronate (ALN) treatment for 10 weeks. Body weight, uterus, femur weight, bone biochemical, bone turnover markers, inflammatory cytokine, calcium, phosphorus, vitamin D (Vit D), urine, hormones, and antioxidant level were estimated. Geraniin significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) reduced the level of bone turnover markers including beta\u2010CrossLaps (\u03b2\u2010CTx), ALN, osteocalcin (OC), alkaline phosphatase (ALP), and bone Gla protein (BGP); reduced the biomechanical parameters including maximum load, energy, stiffness, maximum stress, and Young's modulus; reduced the level of calcium (Ca) and\u00a0phosphorus (P); and increased the level of vitamin D (Vit D) as compared with OVX\u2010induced osteoporosis rats. Geraniin increased the level of bone structure parameters, namely bone mineral density, bone mineral content, tissue mineral density, bone volume fraction, and trabecular number; increased the level of osteoprotegerin (OPG) and\u00a0OPG\/RANKL;\u00a0and reduced the level of receptor activator of nuclear factor kappa\u2010\u0392 ligand (RANKL). Geraniin significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) increased the level of glutathione (GSH) and reduced the level of malonaldehyde (MDA) in the liver, intestine, and bone of OVX\u2010induced osteoporosis rats. Geraniin significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) decreased the level of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin\u20101\u03b2 (IL\u20101\u03b2), and interleukin\u20106 (IL\u20106) pro\u2010inflammatory cytokines. We also argue that geraniin could be an excellent candidate to treat and control bone\u2010related disease or disorders.<\/jats:p>","DOI":"10.1002\/jbt.22774","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T12:34:09Z","timestamp":1616502849000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antiosteoporosis effect of geraniin on ovariectomy\u2010induced osteoporosis in experimental rats"],"prefix":"10.1002","volume":"35","author":[{"given":"Xiuhui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai University of Medicine &amp; Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai University of Medicine &amp; Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai University of Medicine &amp; Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuokai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai University of Medicine &amp; Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai University of Medicine &amp; Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai University of Medicine &amp; Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai University of Medicine &amp; Health Sciences Affiliated Zhoupu Hospital  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8507-2198","authenticated-orcid":false,"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21010\/ajtcam.v14i4.4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afos.2017.07.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00456"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurjrheum.2016.048"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S138000"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112716"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110668"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-11-10"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108650"},{"key":"e_1_2_10_11_1","first-page":"1911","volume":"21","author":"Wang Q. 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