{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:17:58Z","timestamp":1790716678966,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T00:00:00Z","timestamp":1622160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to evaluate the potential of syringic acid (SA) against propylthiouracil (PTU)\u2010induced hypothyroidism in rats. SA at a prestandardized dose, 50\u2009mg\/kg\/day, was orally administered to PTU\u2010induced hypothyroid rats for 30 days, and alterations in the levels of serum triiodothyronine (T\n                    <jats:sub>3<\/jats:sub>\n                    ), thyroxine (T\n                    <jats:sub>4<\/jats:sub>\n                    ), thyrotropin (TSH), alanine transaminase (ALT), and aspartate transaminase (AST); tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) and interleukin\u20106 (IL\u20106); total cholesterol (CHOL) and triglycerides (TG); hepatic lipid peroxidation (LPO) and antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione content), as well as histological changes in liver and thyroid were examined. The molecular interactions of the ligand, SA, with thyroid\u2010related protein targets, such as human thyroid hormone receptor \u03b2 (hTR\u03b2), and thyroid peroxidase (TPO) protein, were studied using molecular docking. Whereas in hypothyroid animals, T\n                    <jats:sub>4<\/jats:sub>\n                    , T\n                    <jats:sub>3<\/jats:sub>\n                    , and antioxidants were decreased, there was an increase in TSH, TNF\u2010\u03b1, IL\u20106, ALT, AST, and hepatic LPO; administration of SA in PTU\u2010induced animals reversed all these indices to near normal levels. SA also improved the histological features of liver and thyroid gland. Our study clearly demonstrates SA as a novel thyroid agonist for augmenting the thyroid functions in rats. Molecular docking analysis reveals that SA possesses good binding affinity toward both the targets, hTR\u03b2 and TPO. Through this approach, for the first time we provide the evidence for SA as a novel thyroid agonist and suggest a receptor\u2010mediated mechanism for its thyroid stimulatory potential.\n                  <\/jats:p>","DOI":"10.1002\/jbt.22814","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T07:41:53Z","timestamp":1622187713000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Syringic acid, a novel thyroid hormone receptor\u2010\u03b2 agonist, ameliorates propylthiouracil\u2010induced thyroid toxicity in rats"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4679-0223","authenticated-orcid":false,"given":"Sunanda","family":"Panda","sequence":"first","affiliation":[{"name":"School of Life Sciences Devi Ahilya University  Indore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Kar","sequence":"additional","affiliation":[{"name":"School of Life Sciences Devi Ahilya University  Indore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Centre University of Texas  Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Ganeshpurkar","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry Banaras Hindu University  Varanasi India"},{"name":"Department of Pharmaceutical Engineering and Technology Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0266"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70030-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-011-9089-7"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.3.1097"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2020.06.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2019.1702656"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.4014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(01)00067-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"C.Srinivasulu M.Ramgopal G.Ramanjaneyulu C. 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