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The present study aimed to reduce oxidative stress\u2010induced hepatic damage resulting from ischemia and reperfusion due to aortic cross\u2010clamping during surgery by means of resveratrol administration. Forty male Sprague\u2013Dawley rats were randomly assigned into four groups: control (healthy), glycerol+ischemia\/reperfusion (I\/R) (sham), I\/R, and I\/R\u2009+\u2009Resveratrol. In all groups scheduled for I\/R, 60\u2009min of shock was followed by 60\u2009min of ischemia. In the I\/R\u2009+\u2009Resveratrol group, 10\u2009mg\/kg of resveratrol was administered 15\u2009min before ischemia and immediately before reperfusion via the intraperitoneal route. In addition, 120\u2009min of reperfusion was applied under anesthesia after ischemia in all groups. Intralobar and interlobar necrosis, vascular congestion, and edematous fields resulting from aortic occlusion were present. Liver tissue malondialdehyde (MDA) levels and cleaved caspase\u20103 positivity increased, while glutathione (GSH) levels decreased. However, resveratrol administration reduced intralobular and interlobar necrosis, vascular congestion and edematous fields, cleaved caspase\u20103 positivity, and MDA levels, and increased GSH levels. Our findings suggest that resveratrol is effective against aortic occlusion\u2010induced liver injury by reducing oxidative stress and apoptosis.<\/jats:p>","DOI":"10.1002\/jbt.22836","type":"journal-article","created":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T10:51:10Z","timestamp":1622631070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The hepatoprotective potential of resveratrol in an experimental model of ruptured abdominal aortic aneurysm via oxidative stress and apoptosis"],"prefix":"10.1002","volume":"35","author":[{"given":"Arzu","family":"Bilen","sequence":"first","affiliation":[{"name":"Department of Endocrinology and metabolism diseases, Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz","family":"Mercantepe","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and metabolism diseases, Faculty of Medicine Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"T\u00fcmkaya","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Recep Tayyip Erdogan University  Rize Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine Recep Tayyip Erdogan University  Rize Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eule","family":"Batcik","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation, Faculty of Medicine Recep Tayyip Erdogan University  Rize Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-016-1401-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001513"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60109-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1457496917738923"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7461\/jcen.2014.16.4.335"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(99)70131-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-2109(03)00075-9"},{"issue":"4","key":"e_1_2_8_9_1","first-page":"41","volume":"35","author":"Shimizu K.","year":"2014","journal-title":"Brazilian J. 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