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Control (<jats:italic>n<\/jats:italic>\u2009=\u20098) rats; rats given EDA (30\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009day<jats:sup>\u22121<\/jats:sup>;<jats:italic>n<\/jats:italic>\u2009=\u200910); rats given only (VPA, 500\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009day<jats:sup>\u22121<\/jats:sup>;<jats:italic>n<\/jats:italic>\u2009=\u200910); rats given VPA\u2009+\u2009EDA (in the same dose and time) for 7 days. EDA and VPA were applied intraperitoneally. After 8 days, lung tissues were immediately taken from the rats. In lung homogenates, reduced glutathione, total antioxidant status levels, and superoxide dismutase, glutathione peroxidase, sodium\/potassium ATPase, paraoxonase1, and carbonic anhydrase activities significantly abated, whereas catalase, glutathione reductase, glutathione\u2010S\u2010transferase activities insignificantly decreased in the VPA\u2010treated group. In contrast, lipid peroxidation, reactive oxygen species, and total oxidant status levels, glycoprotein and protein carbonyl contents, nitric oxide, hydroxyproline levels, and xanthine oxidase, lactate dehydrogenase, arginase, and prolidase activities significantly increased in the VPA\u2010given group. Administration of EDA caused the reverse effects. As a consequence, EDA prevented oxidative stress\u2010mediated lung injury via its robust antioxidant effects.<\/jats:p>","DOI":"10.1002\/jbt.22847","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T13:28:42Z","timestamp":1627306122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effects of edaravone, a free\u2010radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-5096","authenticated-orcid":false,"given":"Bertan B.","family":"Bayrak","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Avcilar\u2010Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-1645","authenticated-orcid":false,"given":"Sebahat","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Avcilar\u2010Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-5015","authenticated-orcid":false,"given":"Neziha","family":"Hacihasanoglu Cakmak","sequence":"additional","affiliation":[{"name":"Pharmacy Services, Vocational School of Health Services Istanbul Medipol University Beykoz\u2010Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-4363","authenticated-orcid":false,"given":"Refiye","family":"Yanardag","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Engineering Istanbul University\u2010Cerrahpa\u015fa Avcilar\u2010Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2017.91"},{"key":"e_1_2_9_3_1","first-page":"537","volume":"33","author":"Wang Y.","year":"2020","journal-title":"J. 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