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Mesenchymal stem cells (MSCs) were affirmed to have therapeutic effects on phosgene\u2010induced ALI. In a previous study, ALI exosomes have been confirmed to promote the proliferation and migration of MSCs. However, the mechanism of this phenomenon is still unclear. MicroRNAs (miRNAs) are essential in the physiological process of cells. In this study, lung\u2010derived exosomes were isolated from phosgene\u2010exposed and normal rats, respectively, through ultracentrifugation and cultured MSCs with these exosomes. We found that rno\u2010miR\u201034c\u20103p was downregulated in MSCs cocultured with ALI exosomes. MiR\u201034c\u20103p inhibitor promoted the proliferation and migration of MSCs. Moreover, the dual\u2010luciferase reporter assay demonstrated that miR\u201034c\u20103p regulated Janus kinase 1 (JAK1) expression. The miR\u201034c\u20103p inhibitor also significantly activated the JAK1\/signal transducer and activator of transcription 3 (STAT3) signaling pathway. In conclusion, ALI exosomes decrease the miR\u201034c\u20103p expression levels, influencing MSCs via the JAK1\/STAT3 signaling pathway.<\/jats:p>","DOI":"10.1002\/jbt.22851","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T18:42:08Z","timestamp":1627756928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lung\u2010derived exosomes regulate the function of mesenchymal stem cells and alleviate phosgene\u2010induced lung injury via miR\u201034c\u20103p"],"prefix":"10.1002","volume":"35","author":[{"given":"Zhi\u2010Feng","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit, Center of Emergency and Intensive Care Unit, Jinshan Hospital Fudan University Shanghai China"},{"name":"Department of Intensive Care Unit, Medical Research Center of Chemical Injury, Jinshan Hospital Fudan University Shanghai China"},{"name":"Department of Intensive 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