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The purpose of the current study was to synthesize and evaluate a curcumin\u2010based reparative endodontic material to reduce infection and inflammation besides the induction of mineralization during the healing of the dentin\u2013pulp complex. Poly\u2010\u025b\u2010caprolactone (PCL)\/gelatin (Gel)\/CUR scaffold was synthesized and assessed by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermo\u2010gravimetric analysis (TGA). Agar diffusion test was performed against <jats:italic>E. coli<\/jats:italic>, <jats:italic>A. baumannii<\/jats:italic>, <jats:italic>P. aeruginosa<\/jats:italic>, <jats:italic>S. aureus<\/jats:italic>, <jats:italic>E. faecalis<\/jats:italic>, and <jats:italic>S. mutans<\/jats:italic>. Moreover, proliferative, antioxidative, anti\u2010inflammatory, and calcification properties of these scaffolds on human dental pulp stem cells (hDPSCs) were evaluated. The results showed that PCL\/Gel\/CUR scaffold had antibacterial effects. Also, these CUR\u2010based scaffolds had significant inhibitory effects on the expression of tumor necrosis factor \u03b1 and DCF from inflamed hDPSCs (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, the induction of mineralization in hDPSCs significantly increased after seeding on CUR\u2010based scaffolds (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Based on these findings, the investigated CUR\u2010loaded material was fabricated successfully and provided an appropriate structure for the attachment and proliferation of hDPSCs. It was found that these scaffolds had antimicrobial, antioxidant, and anti\u2010inflammatory characteristics and could induce mineralization in hDPSCs, which is essential for healing and repairing the injured dentin\u2013pulp complex.<\/jats:p>","DOI":"10.1002\/jbt.22854","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T18:41:07Z","timestamp":1627756867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Synthesis, characterization, and evaluation of curcumin\u2010loaded endodontic reparative material"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-8213","authenticated-orcid":false,"given":"Mahdieh","family":"Alipour","sequence":"first","affiliation":[{"name":"Dental and Periodontal Research Center, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Stem Cell Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaf","family":"Fadakar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marziyeh","family":"Aghazadeh","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center and Department of Oral Medicine, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9284-0055","authenticated-orcid":false,"given":"Roya","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-8795","authenticated-orcid":false,"given":"Hossein","family":"Samadi Kafil","sequence":"additional","affiliation":[{"name":"Drug Applied Research Center, Department of Medical Microbiology, Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Roshangar","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ensieh","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-328X","authenticated-orcid":false,"given":"Zahra","family":"Aghazadeh","sequence":"additional","affiliation":[{"name":"Stem Cell Research Center and Department of Oral Medicine, Faculty of Dentistry Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.114305"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131216104"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2008.01.015"},{"key":"e_1_2_11_6_1","unstructured":"L. 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