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One of its components, <jats:italic>RTG1<\/jats:italic> encoded Rtg1p in association with Rtg3p communicates between mitochondria, nucleus, and peroxisome during stress for adaptation, by regulation of transcription. The F\u2010box motif protein encoded by <jats:italic>YDR131C<\/jats:italic> \u00a0constitutes a part of SCF <jats:sup>Ydr131c<\/jats:sup>\u2010E3 ligase complex, with unknown function; however, it is known that retrograde signaling is modulated by the E3 ligase complex. This study reports epistasis interaction between <jats:italic>YDR131C<\/jats:italic> and <jats:italic>RTG1<\/jats:italic>, which regulates cell growth, response to genotoxic stress, decreased apoptosis, resistance to petite mutation, and cell wall integrity. The cells of <jats:italic>ydr131c\u0394rtg1\u0394<\/jats:italic> genetic background exhibits growth rate improvement however, sensitivity to hydroxyurea, itraconazole antifungal agent and synthetic indoloquinazoline\u2010based alkaloid (8\u2010fluorotryptanthrin, RK64), which disrupts the cell wall integrity in <jats:italic>Saccharomyces cerevisiae<\/jats:italic>. The epistatic interaction between <jats:italic>YDR131C<\/jats:italic> and <jats:italic>RTG1<\/jats:italic> indicates a link between protein degradation and retrograde signaling pathways.<\/jats:p>","DOI":"10.1002\/jbt.22864","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T09:16:42Z","timestamp":1627291002000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic interaction between F\u2010box motif encoding <i>YDR131C<\/i> and retrograde signaling\u2010related <i>RTG1<\/i> regulates the stress response and apoptosis in <i>Saccharomyces cerevisiae<\/i>"],"prefix":"10.1002","volume":"35","author":[{"given":"Heena","family":"Shoket","sequence":"first","affiliation":[{"name":"Genome Stability Regulation Lab, School of Biotechnology Shri Mata Vaishno Devi University  Katra Jammu &amp; Kashmir India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Pandita","sequence":"additional","affiliation":[{"name":"Genome Stability Regulation Lab, School of Biotechnology Shri Mata Vaishno Devi University  Katra Jammu &amp; 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