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Therefore, this study aimed to assess the beneficial\u00a0effect of doxorubicin (Dox) and polydatin (PD) AuNP in Ehrlich ascites carcinoma (EAC) and the ability of PD\u2013AuNP to protect the heart from Dox's deteriorating effects. EAC was induced in mice. The mice were divided into nine groups: normal, EAC, PD: received PD (20\u2009mg\/kg), Dox: received Dox (2\u2009mg\/kg), PD\u2013AuNPH: received 10\u2009ppm AuNP of PD, PD\u2013AuNPL: received 5\u2009ppm AuNP of PD, Dox\u2013AuNP: received Dox\u2013AuNP, PD\u2013Dox\u2013AuNP: received PD\u2013Dox\u2013AuNP, AuNP: received AuNP. On the 21st day from tumor inoculation, the mice were sacrificed and tumor and heart tissues were removed. Tumor \u03b2\u2010catenin\/Cyclin D1 and p53 were assessed by immunohistochemistry. IL\u20106 was determined by enzyme\u2010linked immunosorbent assay. PD\u2013AuNP and Dox\u2013AuNP showed a significant reduction in tumor volume and weight more than their free forms. Also, PD\u2013AuNP and Dox\u2013AuNP showed markedly less dense tumor cells. \u03b2\u2010catenin and Cyclin D1 were markedly decreased and p53 was highly upregulated by PD\u2013AuNP and Dox\u2013AuNP. Moreover, PD\u2013AuNP and Dox\u2013AuNP have the ability to decrease IL\u20106 production. PD\u2013AuNP protected the heart from Dox\u2010induced severe degeneration. Therefore, PD\u2013AuNP could be a tool to decelerate the progression of breast cancer.<\/jats:p>","DOI":"10.1002\/jbt.22869","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T14:40:04Z","timestamp":1627915204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Polydatin gold nanoparticles potentiate antitumor effect of doxorubicin in Ehrlich ascites carcinoma\u2010bearing mice"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7668-7716","authenticated-orcid":false,"given":"Yara A.","family":"Samra","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr M.","family":"Abdelghany","sequence":"additional","affiliation":[{"name":"Department of Spectroscopy, Physics Division National Research Centre Giza Egypt"},{"name":"Basic Science Department Horus University New Damietta Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randa A.","family":"Zaghloul","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Pharmacy Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_10_2_1","author":"Lovelace D.","year":"2019","journal-title":"J. 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