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Hence, the present study was conducted to decipher the neurodegenerative potential of BPA in inducing Parkinson's disease like phenotypes in zebrafish. Zebrafish were subjected to chronic waterborne exposure to BPA for 56 days. Locomotor activities and neurobehavioral response were assessed by the NTDT (novel tank diving test), OFT (open field test), and LDPT (light\u2010dark preference test). The oxidative stress markers and histopathological observation for pyknosis and chromatin condensation were carried out. Immunohistochemistry for activated caspase\u20103 and targeted proteins expression study was performed. The basic findings reveal that chronic BPA exposure significantly induces locomotor dysfunction through a significant decline in mean velocity and total distance traveled. As a measure of pyknosis and chromatin condensation, pyknotic and Hoechst positive neurons in telencephalon and diencephalon significantly increased by BPA exposure. A higher concentration of BPA adversely affects the neurobehavioral response, antioxidant status, and neuromorphology in zebrafish. Parkinson\u2010relevant targeted protein expression viz. alpha\u2010synuclein and LRRK2, were significantly upregulated, whereas tyrosine hydroxylase, NeuN, and Nurr1 were significantly downregulated in the zebrafish brain. As an indicator of cell death by apoptosis, the expression of activated caspase\u20103 was significantly increased in the BPA\u2010exposed zebrafish brain. These basic results of the current study indicate that chronic waterborne exposure to BPA induces neuropathological manifestation leading to the development of motor dysfunction and Parkinsonism\u2010like neurodegenerative phenotypes in zebrafish.<\/jats:p>","DOI":"10.1002\/jbt.22873","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T03:29:03Z","timestamp":1627961343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Bisphenol A exposure induces neurobehavioral deficits and neurodegeneration through induction of oxidative stress and activated caspase\u20103 expression in zebrafish brain"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1505-2893","authenticated-orcid":false,"given":"Pradyumna K.","family":"Sahoo","sequence":"first","affiliation":[{"name":"Neurobiology Laboratory, Centre for Biotechnology Siksha \u2018O\u2019 Anusandhan (Deemed to be University)  Kalinga Nagar Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Aparna","sequence":"additional","affiliation":[{"name":"Neurobiology Laboratory, Department of Zoology Ravenshaw University  Cuttack India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep K.","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Bioinformatics Sambalpur University  Burla India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi B.","family":"Singh","sequence":"additional","affiliation":[{"name":"National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-5333","authenticated-orcid":false,"given":"Saroj K.","family":"Das","sequence":"additional","affiliation":[{"name":"Neurobiology Laboratory, Centre for Biotechnology Siksha \u2018O\u2019 Anusandhan (Deemed to be University)  Kalinga Nagar Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20147"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(00)00507-5"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20746"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12207"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.22072"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.06.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.09.078"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23018-w"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.00184"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.124751"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7713"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.02.023"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0281"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2011.04.005"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2011.05.002"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1051001"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26498-y"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1370"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0742-8413(91)90148-M"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.98106375"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3169"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720207780637234"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.07.009"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.05.039"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.04.021"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.11.035"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.2.7944"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2013.0958"},{"key":"e_1_2_10_30_1","unstructured":"OECD. 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