{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:47:19Z","timestamp":1780613239724,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006054","name":"Universidad de Guanajuato","doi-asserted-by":"publisher","award":["DAIP 0524\/2018"],"award-info":[{"award-number":["DAIP 0524\/2018"]}],"id":[{"id":"10.13039\/501100006054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney injury molecule\u20101 (KIM\u20101) is a membrane receptor upregulated in the proximal tubule cells following various types of kidney injuries. Notably, studies have suggested a correlation between KIM\u20101 expression and extracellular signal\u2010regulated kinase (ERK) activation. In this study, we aimed to investigate the association between the kidney overexpression pattern of cytoplasmic phosphorylated\u2010ERK (p\u2010ERK) protein and increased urinary KIM\u20101 levels in rats exposed to gentamicin or lead acetate, both at the end of toxic exposure and after a 4\u2010week recovery period. Although other proteins were evaluated, only kidney overexpression of cytoplasmic p\u2010ERK protein correlated with increased urinary KIM\u20101 levels. For both toxic substances, the increased urinary KIM\u20101 levels corresponded with kidney inflammation. Our results suggest that KIM\u20101 and p\u2010ERK share a common mechanism in kidney injury mediated by both toxic substances that induce proximal tubule damage.<\/jats:p>","DOI":"10.1002\/jbt.22875","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T06:53:40Z","timestamp":1628146420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between urinary KIM\u20101 and kidney protein expression of p\u2010ERK following damage in rats exposed to gentamicin or lead acetate"],"prefix":"10.1002","volume":"35","author":[{"given":"Carolina","family":"Ruiz\u2010Ramirez","sequence":"first","affiliation":[{"name":"Pharmacy Department, DCNE Universidad de Guanajuato Guanajuato Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro R.","family":"Anta\u00f1o\u2010Martinez","sequence":"additional","affiliation":[{"name":"Pharmacy Department, DCNE Universidad de Guanajuato Guanajuato Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8702-5782","authenticated-orcid":false,"given":"Juvencio","family":"Robles","sequence":"additional","affiliation":[{"name":"Pharmacy Department, DCNE Universidad de Guanajuato Guanajuato Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Gallegos\u2010Corona","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad Aut\u00f3noma de Quer\u00e9taro  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Gallegos\u2010Reyes","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Universidad Aut\u00f3noma de Quer\u00e9taro  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva E.","family":"Avila","sequence":"additional","affiliation":[{"name":"Biology Department, DCNE Universidad de Guanajuato Guanajuato Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4874-3255","authenticated-orcid":false,"given":"Minerva","family":"Martinez\u2010Alfaro","sequence":"additional","affiliation":[{"name":"Pharmacy Department, DCNE Universidad de Guanajuato Guanajuato Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/2175-8239-jbn-2018-0224"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6614848"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2021.1881554"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.7.4135"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007030325"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-016-2700-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.244152"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319826"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.07.020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2013.04.002"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-004-0597-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2009.11.006"},{"issue":"9","key":"e_1_2_10_14_1","first-page":"651","volume":"28","author":"An D. 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