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In this study, we explored the role of umbelliferone against glycerol\u2010induced AKI in rats. Kidney function was assessed by measuring serum creatinine, urea, electrolytes, and microproteinuria. Renal oxidative stress was quantified using thiobarbituric acid reactive substances, superoxide anion generation, and reduced glutathione assay. Renal histological changes were determined using periodic acid Schiff and\u00a0hematoxylin\u2010eosin staining, and immunohistology of apoptotic markers (Bax, Bcl\u20102) was done. Serum creatine kinase was quantified to assess glycerol\u2010induced muscle damage. Umbelliferone attenuated glycerol\u2010induced change in biochemical parameters, oxidative stress, histological alterations, and renal apoptosis. Pretreatment with bisphenol A diglycidyl ether, a peroxisome proliferator\u2010activated receptor\u2010\u03b3 (PPAR\u2010\u03b3) antagonist, attenuated umbelliferone\u2010mediated protection. It is concluded that umbelliferone attenuates glycerol\u2010induced AKI possibly through PPAR\u2010\u03b3 agonism in rats.<\/jats:p>","DOI":"10.1002\/jbt.22892","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T07:38:06Z","timestamp":1629358686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Umbelliferone attenuates glycerol\u2010induced myoglobinuric acute kidney injury through peroxisome proliferator\u2010activated receptor\u2010\u03b3 agonism in rats"],"prefix":"10.1002","volume":"35","author":[{"given":"Tajpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-5345","authenticated-orcid":false,"given":"Damanpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Laboratory, Dietetics and Nutrition Technology Division CSIR\u2010Institute of Himalayan Bioresource Technology  Palampur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy Guru Angad Dev Veterinary and Animal Sciences University  Ludhiana India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrit P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-062X","authenticated-orcid":false,"given":"Balbir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Guru Nanak Dev University  Amritsar India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10693-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1181553"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bfopcu.2017.05.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-019-00973-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22738"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.62.02.0008"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327115618245"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(19)30040-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2017.06.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.03.041"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/549627"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.277.6.F966"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-018-3427-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2818"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.036"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.02.038"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.09.035"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5392"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.06.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.12.047"},{"key":"e_1_2_7_22_1","first-page":"3404","volume":"17","author":"Luo H.","year":"2018","journal-title":"Mol. 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