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Rats were induced myocardial infarction by using isoproterenol (100\u2009mg\/kg body weight [b.w]). Serum creatine kinase\u2010MB, serum cardiac troponin\u2010T, heart weight, heart rate, and heart lipid peroxidation were greatly (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.05) augmented, while heart enzymatic antioxidants and plasma nonenzymatic antioxidants were greatly (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.05) lessened in isoproterenol\u2010treated rats. Reverse transcription\u2010polymerase chain reaction study revealed augmented expressions of Fas\u2010receptor and caspases 8, 9, and 3 genes in myocardial infarcted rats. Furthermore, iNOS protein expression was amplified and eNOS protein was lessened in the myocardial infarcted heart. Three weeks pre\u2010 and cotreatment with \u03b2\u2010caryophyllene (20\u2009mg\/kg b.w) greatly (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.05) protected isoproterenol\u2010treated rats against these altered structural, biochemical, molecular, and immunohistochemical parameters, by its anti\u2010cardiac hypertrophic, anti\u2010tachycardial, antioxidant, anti\u2010apoptotic, and anti\u2010endothelial dysfunction effects. In conclusion, these findings projected the use of \u03b2\u2010caryophyllene for the therapy of human myocardial infarction after clinical trials.<\/jats:p>","DOI":"10.1002\/jbt.22907","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T07:10:04Z","timestamp":1637737804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["\u03b2\u2010Caryophyllene inhibits Fas\u2010 receptor and caspase\u2010mediated apoptosis signaling pathway and endothelial dysfunction in experimental myocardial infarction"],"prefix":"10.1002","volume":"35","author":[{"given":"Anita","family":"Yovas","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University Chidambaram Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-4074","authenticated-orcid":false,"given":"Stanely Mainzen Prince","family":"Ponnian","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Annamalai University Chidambaram Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"443","volume":"67","author":"Rona G.","year":"1959","journal-title":"AMA Arch. 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