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Urothelial cancer\u2010associated 1 (UCA1) functions as an oncogene in the development of acute myeloid leukemia. However, the association between DNMT1 and UCA1 with benzene or HQ exposure has not been explored. We characterized UCA1 expression in cells briefly exposed to HQ (HQ\u2010ST cells) and HQ\u2010induced malignantly transformed (TK6\u2010HT cells) treated with 5\u2010aza\u20102\u02b9\u2010deoxycytidine (5\u2010AzaC) or trichostatin A (TSA). Compared to that in control cells, UCA1 expression was increased, whereas DNMT1 was decreased in HQ\u2010ST cells and TK6\u2010HT cells treated with 5\u2010AzaC or TSA. Moreover, UCA1 expression was also upregulated and positively correlated with benzene exposure time in benzene\u2010exposed workers. Furthermore, the expression of UCA1 was negatively associated with the DNA methylation level of its promoter in benzene\u2010exposed workers. DNMT1 rather than DNMT3b knockout in TK6\u2010HT cells activated the expression of UCA1 by inducing its promoter hypomethylation. These results suggest that benzene or HQ exposure leads to UCA1 upregulation via DNA hypomethylation in the UCA1 promoter, which is mediated by DNMT1.<\/jats:p>","DOI":"10.1002\/jbt.22920","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T17:58:28Z","timestamp":1633715908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The DNMT1\u2010associated lncRNA UCA1 was upregulated in TK6 cells transformed by long\u2010term exposure to hydroquinone and benzene\u2010exposed workers via DNA hypomethylation"],"prefix":"10.1002","volume":"35","author":[{"given":"Zhijie","family":"Pan","sequence":"first","affiliation":[{"name":"Dongguan Key Laboratory of Environmental Medicine School of Public Health, Guangdong Medical University  Dongguan China"},{"name":"Department of Preventive Medicine Guangdong Medical University  Dongguan 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