{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:23:09Z","timestamp":1784161389076,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aluminum phosphide (AlP) is commonly used as a powerful suicidal tool. The exact mechanism of acute toxicity has not been well defined despite high mortality rates as well as its supportive treatment including rapid decontamination and institution of resuscitative measures. The current study aimed to investigate a new combination therapy using trimetazidine, <jats:italic>N<\/jats:italic>\u2010acetyl cysteine, vitamin C, and hyperinsulinemia\u2013euglycemia to manage acute AlP poisoning. Acute AlP\u2010induced cardiotoxicity, hemodynamic changes, and hepatotoxicity were evaluated using electrocardiogram, creatinine kinase MB iso\u2010enzyme, troponin\u20101, blood pressure, random blood glucose level, liver function tests, and histopathological changes in both the heart and liver in a rabbit model of AlP poisoning. The results showed that the new regimen therapy ameliorates the toxic effect of AlP with significant improvement in survival, cardiovascular and hemodynamic parameters in addition to histopathological changes. These results highlight the strong cardioprotective, antioxidant, hepatoprotective effects of the new combined therapy along with correction of hemodynamic changes and hyperglycemia as a potential target in the management of acute AlP poisoning.<\/jats:p>","DOI":"10.1002\/jbt.22931","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T11:10:32Z","timestamp":1634814632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trimetazedine with hyperinsulinimea\u2013euoglycemia, <i>N<\/i>\u2010acetyl cysteine, and vitamin C: A new approach concept for management of aluminum phosphide poisoning"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6027-2823","authenticated-orcid":false,"given":"Doaa M.","family":"El Shehaby","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine &amp; Clinical Toxicology, Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa M.","family":"Abd El\u2010Kareem","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghda","family":"Elsherif","sequence":"additional","affiliation":[{"name":"Department of Histology, Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"Almaz","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine &amp; Clinical Toxicology, Faculty of Medicine Assiut University  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21608\/ajfm.2020.68598"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13156"},{"issue":"1","key":"e_1_2_10_4_1","first-page":"111","volume":"28","author":"Wahdan A.","year":"2020","journal-title":"Mansoura J. Forensic Med. Clin. Toxicol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/2008-2231-20-25"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154055"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0525-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.18295\/squmj.2018.18.03.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327117694074"},{"issue":"22","key":"e_1_2_10_10_1","first-page":"34","volume":"2","author":"Mehrpour O.","year":"2008","journal-title":"Indian J. Forensic Med. Toxicol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2478\/10004-1254-63-2012-2182"},{"key":"e_1_2_10_12_1","first-page":"173","volume":"112","author":"Ramezani\u2010Aliakbari F.","year":"2019","journal-title":"Arq. Bras. Cardiol"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/107424840400900104"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004349"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2020.05.016"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1191\/0960327104ht456oa"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0532-9"},{"issue":"1","key":"e_1_2_10_18_1","first-page":"10","volume":"1","author":"Sallam S. M. A.","year":"2005","journal-title":"Res. J. Agri. Biol. Sci"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2478\/aiht-2018-69-3106"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2005.032615"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.743029"},{"issue":"4","key":"e_1_2_10_22_1","first-page":"27","volume":"31","author":"Regulatory G.","year":"2010","journal-title":"Prescriber Update"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2009.12.005"},{"key":"e_1_2_10_24_1","first-page":"37","volume":"3","author":"Abdi\u2010Azar H.","year":"2014","journal-title":"Bull. Environ. Pharmacol. Life Sci"},{"key":"e_1_2_10_25_1","unstructured":"Theory and Practice of Histological Techniques (Eds: J. D. Bancroft M. Gamble) 7th ed. Elsevier Health Sciences Nottingham UK 2008 p. 51."},{"key":"e_1_2_10_26_1","first-page":"15","volume":"7","author":"\u00d6zdemir H.","year":"2020","journal-title":"Exp. Anim"},{"key":"e_1_2_10_27_1","first-page":"113","volume":"13","author":"O'Callaghan J.","year":"1992","journal-title":"Neurotoxicology"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9903.164225"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2012007500019"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319714530040"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.027"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.11.060"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1191\/0960327105ht496oa"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2006.05.033"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2018.10.009"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-136"},{"key":"e_1_2_10_37_1","first-page":"19","volume":"8","author":"T\u00fcmer K. \u00c7.","year":"2019","journal-title":"Exp. Anim"},{"key":"e_1_2_10_38_1","volume":"4","author":"Mair J.","year":"2015","journal-title":"Reprod. Toxicol"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02206-8"},{"key":"e_1_2_10_40_1","first-page":"333","volume":"3","author":"Sharma D.","year":"2014","journal-title":"Indian Med. Gaz"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(88)90338-3"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00804-4"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12481"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2559"},{"key":"e_1_2_10_45_1","first-page":"293","volume":"35","author":"Turkez H.","year":"2011","journal-title":"Turk. J. Biol"},{"key":"e_1_2_10_46_1","first-page":"177","volume":"48","author":"Sinha U.","year":"2005","journal-title":"Indian J. Pathol. Microbiol"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2007.12.007"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-736X2016000700002"},{"key":"e_1_2_10_49_1","first-page":"380","volume":"93","author":"Arora B.","year":"1995","journal-title":"J. Indian Med. Assoc"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.53117"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.09.019"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.67"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700554200"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040602"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00546.2005"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22931","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.22931","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T06:17:03Z","timestamp":1692425823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/jbt.22931"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22931","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,19]]},"assertion":[{"value":"2021-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22931"}}