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Membrane nephropathy may be either idiopathic or primary, not recognized (70%\u201380%) or secondary (20%\u201330%) to pathological sicknesses such as hepatitis B, systemic lupus erythematosus, malignancies, and side\u2010effects of medicines. The immunological responses in MN involve\u00a0multiple components: immunoglobulin G (IgG), long\u2010escaped antigens, and the membrane attachment complex, formed by the supplement to form C5b\u20109. In general, IgG4 is the most significant IgG subclass deposited in idiopathic membranous nephropathic disease but fluctuating IgG1 levels also are linked with immunological deposits. In contrast, IgG1, IgG2, and IgG3 deposition are greater than IgG4 deposition in secondary nephropathy. Fluconazole is a synthetic antifungal triazole that is often used. It is well tolerated in general and has\u00a0never been identified as a cause of nephropathies. We report on the development of MN caused by fluconazole therapy that could potentiate podocyte autophagy.<\/jats:p>","DOI":"10.1002\/jbt.22935","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T13:08:18Z","timestamp":1635858498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immune\u2010mediated membranous nephropathy: Long term fluconazole usage caused podocyte autophagy"],"prefix":"10.1002","volume":"36","author":[{"given":"Lan","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Nephrology Affiliated Hospital of Chengde Medical University, Chengde  Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Juan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Nephrology Affiliated Hospital of Chengde Medical University, Chengde  Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao\u2010Rong","family":"Dong","sequence":"additional","affiliation":[{"name":"Division of Nephrology Affiliated Hospital of Chengde Medical University, Chengde  Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6798-5663","authenticated-orcid":false,"given":"Gui\u2010Cai","family":"Hu","sequence":"additional","affiliation":[{"name":"Division of Nephrology Affiliated Hospital of Chengde Medical University, Chengde  Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"268","volume":"20","author":"Ponticelli C.","year":"2007","journal-title":"J. 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