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The mycotoxin ZEN contaminates crops, causing toxicity on ingestion, economic losses, and alters reproductive function. Relative to control, GA reversed ZEN\u2010induced reduction of rats' testicular function enzymes and reproductive hormones and improved ZEN\u2010impaired sperm quality. GA significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) increased rats antioxidant status, inhibited (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) reactive oxygen and nitrogen species and lipid peroxidation levels, and abated (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) proinflammatory biomarkers in the examined organs: hypothalamus, testis, and epididymis. Histopathology revealed that GA facilitated the preservation of testicular and epididymal cytoarchitecture significantly altered in rat cohorts treated with ZEN alone. Conclusively, GA protected against ZEN\u2010induced toxicity in the rats' organs examined, enhanced endogenous antioxidative protective mechanism, and abated proinflammatory responses. GA further averted a decline in circulatory, reproductive enzymes, hormone levels. GA also protected against reproductive tissue damage and improved parameters of sperm functionality.<\/jats:p>","DOI":"10.1002\/jbt.22940","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T10:52:41Z","timestamp":1635763961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Coadministration of gallic acid abates zearalenone\u2010mediated defects in male rat's reproductive function"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4973-0376","authenticated-orcid":false,"given":"Solomon E.","family":"Owumi","sequence":"first","affiliation":[{"name":"Department of Biochemistry, CRMBL Unit Faculty of Basic Medical Sciences, ChangeLab  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel A.","family":"Bello","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences, Nutrition and Industrial Biochemistry Laboratories University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Najophe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Basic Medical Sciences, Nutrition and Industrial Biochemistry Laboratories University of Ibadan  Ibadan Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"O. 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