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Their characterization was performed by UV\u2010Visible analysis, fourier transform infrared spectroscopy, transmission electron microscopy (TEM), scanning electron microscope (SEM), and Zeta analyses. In in vivo studies, albino rats (180\u2009\u00b1\u200910\u2009g) were persuaded with model hepatic toxicant <jats:italic>N<\/jats:italic>\u2010nitrosodiethylamine (NDEA) and subsequently cotreated with <jats:italic>Morus multicaulis<\/jats:italic> at 100\u2009mg\/kg and AgNPs at 100\u2009\u00b5g\/kg dose. NDEA administration elevates the levels of liver function test biomarkers, which were reinstated to normal by cotreatment of test drugs. The oxidative stress and concentration of drug\u2010metabolizing enzyme increase after induction of toxicant (NDEA), these markers are restored toward normal after cotreatment of nano\u2010drug. Treatments of <jats:italic>M. multicaulis<\/jats:italic> extract did not show such significant protection. The NDEA\u2010treated groups showed a significant rise in the level of cytokines (interleukin\u00a0[IL\u20106] and IL\u201010) and reached normal with subsequent treatment with AgNPs. Histopathological studies also exhibited the curative effect of AgNPs in the same manner. Thus current results strongly suggest that biomimetic AgNPs could be used as an effective drug against hepatic alteration.<\/jats:p>","DOI":"10.1002\/jbt.22968","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T09:04:22Z","timestamp":1637917462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biomimetic synthesis of silver nanoparticles for treatment of <i>N\u2010<\/i>Nitrosodiethylamine\u2010induced hepatotoxicity"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-5805","authenticated-orcid":false,"given":"Asha","family":"Singh","sequence":"first","affiliation":[{"name":"Reproductive Biology and Toxicology Laboratory, UNESCO\u2010Trace Element Satellite Centre, School of Studies in Zoology Jiwaji University Gwalior Madhya Pradesh India"},{"name":"Amity Institute of Biotechnology Amity University Gwalior Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Yaqoob","family":"Dar","sequence":"additional","affiliation":[{"name":"Reproductive Biology and Toxicology Laboratory, UNESCO\u2010Trace Element Satellite Centre, School of Studies in Zoology Jiwaji University Gwalior Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Durga P.","family":"Nagar","sequence":"additional","affiliation":[{"name":"Division of Toxicology, Defence Research &amp; Development Establishment Gwalior Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh S.","family":"Tomar","sequence":"additional","affiliation":[{"name":"Amity Institute of Biotechnology Amity University Gwalior Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhana","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Reproductive Biology and Toxicology Laboratory, UNESCO\u2010Trace Element Satellite Centre, School of Studies in Zoology Jiwaji University Gwalior Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Shukla","sequence":"additional","affiliation":[{"name":"Reproductive Biology and Toxicology Laboratory, UNESCO\u2010Trace Element Satellite Centre, School of Studies in Zoology Jiwaji University Gwalior Madhya Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.021"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2017.11.011"},{"issue":"5","key":"e_1_2_10_4_1","first-page":"233","volume":"2","author":"Pandit A.","year":"2012","journal-title":"J. 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