{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:45:34Z","timestamp":1782906334615,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schiff bases are compounds that have gained importance in the paint industry due to their colorful nature and in the field of chemistry and biochemistry due to their biological activities. Various biological applications of Schiff bases, such as antitumor, antifungal, antibacterial, antioxidant, antituberculosis, and anthelmintic, have been widely studied. Within the scope of the study, 5\u2010bromo\u20102\u2010hydroxybenzaldehyde and amino acid methyl esters (isoleucine, phenylalanine, and methionine) and amino acid Schiff bases were synthesized first. The synthesis of the new Zn(II) complexes of these Schiff bases was carried out by the reaction of synthesized Schiff bases and Zn(OAc)<jats:sub>2<\/jats:sub>\u00b72H<jats:sub>2<\/jats:sub>O. The structures of the synthesized complexes were elucidated using elemental analysis, Fourier transform infrared, nuclear magnetic resonance, UV\u2010visible, and thermal analysis spectroscopy techniques. These synthesized salts were found to be effective inhibitor compounds for the \u03b1\u2010glycosidase, and acetylcholinesterase enzyme with Ki values in the range of 30.50\u2009\u00b1\u20093.82\u201338.17\u2009\u00b1\u20096.26\u2009\u00b5M for \u03b1\u2010glycosidase, 3.68\u2009\u00b1\u20090.54\u201310.27\u2009\u00b1\u20091.68\u2009\u00b5M for butyrylcholinesterase, and 6.26\u2009\u00b1\u20090.83\u201315.73\u2009\u00b1\u20094.73\u2009\u00b5M for acetylcholinesterase, respectively.<\/jats:p>","DOI":"10.1002\/jbt.22969","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T12:51:36Z","timestamp":1637671896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Novel amino acid Schiff base Zn(II) complexes as new therapeutic approaches in diabetes and Alzheimer's disease: Synthesis, characterization, biological evaluation, and molecular docking studies"],"prefix":"10.1002","volume":"36","author":[{"given":"Ay\u015feg\u00fcl","family":"\u015eenocak","sequence":"first","affiliation":[{"name":"Chemistry Department, Art and Science Faculty Tokat Gaziosmanpasa University Tokat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilay A.","family":"Ta\u015f","sequence":"additional","affiliation":[{"name":"Chemistry Department, Art and Science Faculty Tokat Gaziosmanpasa University Tokat Turkey"},{"name":"Department of Biotechnology, Faculty of Science Bartin University Bartin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Faculty of Science Bartin University Bartin Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"T\u00fcz\u00fcn","sequence":"additional","affiliation":[{"name":"Chemistry Department, Science Faculty Sivas Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aydin","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science Yozgat Bozok University Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Karada\u011f","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Sciences Yozgat Bozok University Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","first-page":"103","volume":"47","author":"Singh H. L.","year":"1999","journal-title":"Bull. Pol. Acad. Sci., Chem."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2010.03.029"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104082"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104171"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.128666"},{"key":"e_1_2_9_7_1","first-page":"1\u201013","author":"Huseynova A.","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000202"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.128210"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103969"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104066"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1792345"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000109"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apt.2020.05.020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22566"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000118"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2020.101711"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000075"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1790422"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.128582"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1134\/S207020512003003X"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/om9009153"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103897"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103884"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103924"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2761"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104216"},{"key":"e_1_2_9_29_1","first-page":"1\u201010","author":"Turkan F.","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"e_1_2_9_30_1","unstructured":"D.Ritchie T.Orpailleur Hex 8.0. 0 User Manual. Protein Docking Using Spherical Polar Fourier Correlations 1996."},{"key":"e_1_2_9_31_1","volume-title":"Gaussian 09, RevisionD.01","author":"Frisch M. J.","year":"2009"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml400304w"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006850"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.01.035"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2019.117861"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.05.130"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2018.05.055"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.01.016"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2017.12.013"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2019.05.007"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2019.136677"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00411a013"},{"issue":"12","key":"e_1_2_9_43_1","first-page":"1152","volume":"58","author":"Ramanujam V. V.","year":"1981","journal-title":"J. Indian Chem. Soc."},{"key":"e_1_2_9_44_1","first-page":"1\u201011","author":"Ko\u00e7yi\u011fit \u00dc. M.","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13738-019-01835-8"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2019.117663"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40735-018-0185-5"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000102"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103762"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2020.112511"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.5802"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.127802"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103647"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/cryst10030171"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22969","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.22969","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T04:24:05Z","timestamp":1693110245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1002\/jbt.22969"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22969","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]},"assertion":[{"value":"2021-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22969"}}