{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:52:56Z","timestamp":1790009576629,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["vide file no. CRG\/2020\/000412"],"award-info":[{"award-number":["vide file no. CRG\/2020\/000412"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetes comorbidity in ulcerative colitis (UC) has relevant clinical and therapeutic implications. The link between hyperglycemia and intestinal barrier function with respect to infection and inflammation consequences exists\u00a0in diabetes. The present study was designed to decipher the molecular mechanisms associated with Type 1 Diabetes mellitus and the UC in both male and female BALB\/c mice. Dextran sulfate sodium (DSS; 2.5%w\/v) dissolved in drinking water was given for three cycles (each cycle; 7 days) with 7 days recovery period in\u2010between to both male and female BALB\/c mice. At the first recovery period, Streptozotocin (40\u2009mg\/kg; i.p.) was administered for 5 consecutive days in the case of male BALB\/c mice; whereas the same procedure was repeated at the beginning of each recovery period in female animals. In the DSS\u2009+\u2009DB\u00a0group of male animals, disease activity index, myeloperoxidase activity, nitrite level, plasma lipopolysaccharides, interleukin\u20101\u03b2, histological score, % fibrotic area, % TUNEL positive cells were significantly increased. Furthermore, protein expression of phosphorylated nuclear factor kappa light chain enhancer of activated B cells (pNF\u03baB65), proliferating cell nuclear antigen, interleukin\u20106, apoptosis\u2010associated speck\u2010like protein containing a caspase\u2010recruitment domain, and cysteine\u2010containing aspartate\u2010specific proteases\u20101 (caspase\u20101) significantly increased in the DSS\u2009+\u2009DB group of male animals as compared to female. The present study findings proved that hyperglycemic conditions exacerbated the pathological conditions in UC of male animals; whereas milder conditions developed in females.<\/jats:p>","DOI":"10.1002\/jbt.22980","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T02:28:42Z","timestamp":1640744922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of Type 1 diabetes with ulcerative colitis in BALB\/c mice: Investigations on sex\u2010specific differences"],"prefix":"10.1002","volume":"36","author":[{"given":"Shivani","family":"Singla","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Facility for Risk Assessment and Intervention Studies National Institute of Pharmaceutical Education and Research S.A.S. Nagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chittaranjan","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Facility for Risk Assessment and Intervention Studies National Institute of Pharmaceutical Education and Research S.A.S. Nagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-7252","authenticated-orcid":false,"given":"Gopabandhu","family":"Jena","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Facility for Risk Assessment and Intervention Studies National Institute of Pharmaceutical Education and Research S.A.S. Nagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.10.020"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1525s104"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.19320"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0325"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02048105"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i33.11496"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.978817"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-018-1867-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.04.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12424"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13021"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14472"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.13.130"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.02.021"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i13.3507"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.06.025"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i33.6016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.06.020"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0547s70"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00630"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.78"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22274"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2013.04.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.08.018"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144630"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10520295.2016.1179342"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22549"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.100998"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201200333"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504701"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.09.010"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0180-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2020.01.003"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123007"},{"key":"e_1_2_8_38_1","first-page":"e22236","author":"Ding C.","year":"2018","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"e_1_2_8_39_1","first-page":"e1004","volume":"9","author":"Hansberry D. R.","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/843089"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22312"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2016.05.011"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010057"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22476"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133175"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2018.060"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.06.021"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.15430\/JCP.2019.24.3.173"}],"container-title":["Journal of Biochemical and Molecular Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22980","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jbt.22980","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jbt.22980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T16:03:34Z","timestamp":1692979414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jbt.22980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,28]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/jbt.22980"],"URL":"https:\/\/doi.org\/10.1002\/jbt.22980","archive":["Portico"],"relation":{},"ISSN":["1095-6670","1099-0461"],"issn-type":[{"value":"1095-6670","type":"print"},{"value":"1099-0461","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,28]]},"assertion":[{"value":"2021-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22980"}}