{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:29Z","timestamp":1786977989771,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Pneumonia is a serious pediatric lung injury disease caused by\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      (\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      ) with increasing global prevalence every year. The WHO has reported that nearly 19% of children die due to pneumonia worldwide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The present research was conducted\u00a0to discover the ameliorative properties of geraniol against\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      \u2010provoked pneumonia in mice through the modulation of inflammatory responses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      The pneumonia was provoked in the male Swiss albino mice via infecting animals with 100\u2009\u00b5l of\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      for 2 days and supplemented concurrently with 20\u2009mg\/kg of geraniol for 3 days. 100\u2009mg\/kg of azithromycin was used as a standard drug. The nitric oxide (NO) level and MPO activity were measured using kits. The SOD activity, GSH, and MDA levels were studied using standard methods. The polymerase chain reaction (PCR) study was performed to examine the\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      DNA\u00a0load. The inflammatory cytokines status was assessed by assay kits. The ERK1\/2, JNK1\/2, and NF\u2010\u03baB expressions were studied by reverse\u2010transcription (RT\u2010PCR). The lung tissues were analyzed microscopically to investigate the histological alterations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Geraniol treatment effectively reduced lung weight, NO level, and MPO activity in the pneumonia mice. The total cells and\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      DNA load were also decreased by the geraniol. The SOD activity and GSH level were improved and MDA was decreased by the geraniol treatment. The IL\u20101, IL\u20106, IL\u20108, TNF\u2010\u03b1, and TGF status were appreciably depleted by the geraniol in the pneumonia mice. Geraniol also suppressed the ERK1\/2 and NF\u2010\u03baB expressions in the lung tissues.\u00a0Histological findings also suggest the therapeutic roles of geraniol against pneumonia in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In summary, our results proved the beneficial roles of geraniol against the\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      \u2010provoked pneumonia. Geraniol could be a hopeful therapeutic agent to treat pneumonia in the future.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jbt.22984","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T09:14:01Z","timestamp":1642410841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Geraniol relieves mycoplasma pneumonia infection\u2010induced lung injury in mice through the regulation of ERK\/JNK and NF\u2010\u03baB signaling pathways"],"prefix":"10.1002","volume":"36","author":[{"given":"Yang\u2010Shan","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Affiliated Hospital of Yunnan University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Qiong","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Affiliated Hospital of Yunnan University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Run","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Sichuan University School of Clinical Medicine Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Yan\u2010Yan\u2010Fei","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, The third affiliated hospital of Kunming Medical University Tumor Hospital of Yunnan Province Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Affiliated Hospital of Yunnan University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Dan","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Affiliated Hospital of Yunnan University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Hu","sequence":"additional","affiliation":[{"name":"Emergency Department Kunming Second People's Hospital Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Li","family":"Xia","sequence":"additional","affiliation":[{"name":"Research centre of Pharmacology and Application of Traditional Chinese Medicine, School of Chinese Materia Medica Yunnan University of Traditional Chinese Medicine Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Ru","family":"Wang","sequence":"additional","affiliation":[{"name":"Research on the Prevention and Treatment of Emergency in the Department of Internal Medicine of Traditional Chinese Medicine, the First Clinical School of Yunnan University of Traditional Chinese Medicine Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-0236","authenticated-orcid":false,"given":"Zhong\u2010Feng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Affiliated Hospital of Yunnan University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1380-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195288"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268819000839"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23095"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00114-16"},{"key":"e_1_2_8_7_1","first-page":"179","volume":"116","author":"Kassisse E.","year":"2018","journal-title":"Arch. 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