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In the current study, we aimed to investigate the effects of bone\u2010marrow\u2010derived mesenchymal stem cell (BM\u2010MSC) administration on DOX\u2010induced hepatotoxicity in rats. 24 Wistar\u2010albino rats were divided into three groups: Control, DOX, and DOX+MSC. DOX (20\u2009mg\/kg) was administered to the DOX group. In the DOX\u2009+\u2009MSC group, BM\u2010MSCs (2\u2009\u00d7\u200910<jats:sup>6<\/jats:sup>) were given through the tail vein following DOX administration. DOX administration led to significant structural liver injury. Besides this, oxidative balance in the liver was impaired following DOX administration. DOX administration also led to an increase in apoptotic cell death in the liver. Structural and oxidative changes were significantly alleviated with the administration of BM\u2010MSCs. Furthermore, BM\u2010MSC administration suppressed excessive apoptotic cell death. Our findings revealed that BM\u2010MSC administration may alleviate DOX\u2010induced liver injury via improving the oxidative status and limiting apoptotic cell death in the liver tissue.<\/jats:p>","DOI":"10.1002\/jbt.22985","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T13:09:10Z","timestamp":1646053750000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of bone marrow\u2010derived mesenchymal stem cells on doxorubicin\u2010induced liver injury in rats"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-8104","authenticated-orcid":false,"given":"Tugba","family":"Celik Samanci","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Recep Tayyip Erdogan University  Rize Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4382-5443","authenticated-orcid":false,"given":"Alpaslan","family":"G\u00f6kcimen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Aydin Adnan Menderes University  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-8775","authenticated-orcid":false,"given":"Mehtap","family":"Kilic Eren","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Aydin Adnan Menderes University  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3904-0985","authenticated-orcid":false,"given":"Kadri Murat","family":"G\u00fcrses","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Aydin Adnan Menderes University  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1455-7283","authenticated-orcid":false,"given":"Hatice","family":"Pilevneli","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Medicine Aydin Adnan Menderes University  Aydin Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6289-0860","authenticated-orcid":false,"given":"Yurdun","family":"Kuyucu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Cukurova University  Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071555"},{"key":"e_1_2_9_3_1","first-page":"40","volume":"5","author":"Zhao X.","year":"2020","journal-title":"Life Sci."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920010791110890"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/jbcpp-2016-0194"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2015.08.017"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2019.02.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1521020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8296451"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.02.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.23242"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v11.i9.604"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0117"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2961-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.08.007"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14788"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1890"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327107076885"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.01.013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001887"},{"key":"e_1_2_9_21_1","unstructured":"H.Ali H.Fikry. 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